Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis

Kinga Németh, Klaus Salchert, Péter Putnoky, Rishikesh Bhalerao, Zsuzsanna Koncz-Kálmán, Biljana Stankovic-Stangeland, László Bakó, Jaideep Mathur, László Ökrész, Sylvia Stabel, Peter Geigenberger, Mark Stitt, George P. Rédei, Jeff Schell, Csaba Koncz

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184 Citations (Scopus)

Abstract

The prl1 mutation localized by T-DNA tagging on Arabidopsis chromosome 4-44 confers hypersensitivity to glucose and sucrose. The prl1 mutation results in transcriptional derepression of glucose responsive genes defining a novel suppressor function in glucose signaling. The prl1 mutation also augments the sensitivity of plants to growth hormones including cytokinin, ethylene, abscisic acid, and auxin; stimulates the accumulation of sugars and starch in leaves; and inhibits root elongation. PRL1 encodes a regulatory WD protein that interacts with ATHKAP2, an α-importin nuclear import receptor, and is imported into the nucleus in Arabidopsis. Potential functional conservation of PRL1 homologs found in other eukaryotes is indicated by nuclear localization of PRL1 in monkey COS-1 cells and selective interaction of PRL1 with a nuclear protein kinase C-βII isoenzyme involved in human insulin signaling.

Original languageEnglish
Pages (from-to)3059-3073
Number of pages15
JournalGenes and Development
Volume12
Issue number19
DOIs
Publication statusPublished - Oct 1 1998

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Keywords

  • Cell elongation
  • Glucose repression
  • Hormone sensitivity
  • WD-40 protein
  • α- importin

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Németh, K., Salchert, K., Putnoky, P., Bhalerao, R., Koncz-Kálmán, Z., Stankovic-Stangeland, B., Bakó, L., Mathur, J., Ökrész, L., Stabel, S., Geigenberger, P., Stitt, M., Rédei, G. P., Schell, J., & Koncz, C. (1998). Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis. Genes and Development, 12(19), 3059-3073. https://doi.org/10.1101/gad.12.19.3059