Platelet 3H-imipramine binding in major depressive episodes

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Density (B(max)) and affinity constant (K(d)) values of tritiated imipramine binding sites were determined on platelets from patients suffering from major depression and from healthy, age-and sex-matched controls. Significantly lower B(max) values were found in the depressed patients, while the K(d) values did not differ from those of controls. The results suggest that, in accordance with data from the literature, decrease in 3H-imipramine binding sites may be used as a state-dependent biological marker of depression in clinical practice.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalEuropean Psychiatry
Issue number2
Publication statusPublished - Jan 1 1991


ASJC Scopus subject areas

  • Psychiatry and Mental health

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