Platelet phospholipids in thrombocytosis due to myeloproliferative disorders

J. H. Breuer, V. Harsanyi, V. Solti, S. Hollán

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Platelet phospholipids were analyzed in patients with thrombocytosis due to myeloproliferative disorders and secondary thrombocytosis. A significant increase of phosphatidylcholine together with a decrease of sphingomyelin was observed in each of the 8 patients with primary thrombocytopenia and in each of the 5 patients with excessive thrombocytosis due to primary polycythaemia. The phospholipid pattern of the 3 patients with secondary thrombocytosis did not differ from that of the normal controls. This marked difference in the platelet phospholipids may be helpful in distinguishing secondary thrombocytosis persisting for a prolonged period of time after splenectomy from previously unrecognized primary thrombocythaemia unmasked by splenectomy. The decreased sphingomyelin/lecithin ratio of platelets in primary thrombocythaemia may interfere with platelet function by increasing the fluidity of their membrane

Original languageEnglish
Pages (from-to)134-140
Number of pages7
JournalHaemostasis
Volume10
Issue number3
Publication statusPublished - 1981

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Thrombocytosis
Myeloproliferative Disorders
Phospholipids
Blood Platelets
Essential Thrombocythemia
Sphingomyelins
Splenectomy
Polycythemia Vera
Membrane Fluidity
Lecithins
Phosphatidylcholines
Thrombocytopenia

ASJC Scopus subject areas

  • Hematology

Cite this

Platelet phospholipids in thrombocytosis due to myeloproliferative disorders. / Breuer, J. H.; Harsanyi, V.; Solti, V.; Hollán, S.

In: Haemostasis, Vol. 10, No. 3, 1981, p. 134-140.

Research output: Contribution to journalArticle

Breuer, JH, Harsanyi, V, Solti, V & Hollán, S 1981, 'Platelet phospholipids in thrombocytosis due to myeloproliferative disorders', Haemostasis, vol. 10, no. 3, pp. 134-140.
Breuer, J. H. ; Harsanyi, V. ; Solti, V. ; Hollán, S. / Platelet phospholipids in thrombocytosis due to myeloproliferative disorders. In: Haemostasis. 1981 ; Vol. 10, No. 3. pp. 134-140.
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