Platelet activating factor, the trigger of haemostatic alterations in rat anaphylaxis

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Abstract

Platelet activating factor (PAF) generated by an IgE mediated reaction in the peritoneal cavity of rats was partially purified by adsorption to diatomaceous earth. It aggregated rat platelets and, as a consequence, activated Hageman factor in in vitro, as well as in in vitro, conditions. The heamostatic alterations induced by PAF showed similarity to those observed in the early phase of rat anaphylaxis.

Original languageEnglish
Pages (from-to)512-515
Number of pages4
JournalClinical and Experimental Immunology
Volume27
Issue number3
Publication statusPublished - 1977

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Platelet Activating Factor
Anaphylaxis
Hemostatics
Diatomaceous Earth
Factor XII
Peritoneal Cavity
Immunoglobulin E
Adsorption
Blood Platelets
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Platelet activating factor, the trigger of haemostatic alterations in rat anaphylaxis. / Fésüs, L.; Csaba, B.; Muszbek, L.

In: Clinical and Experimental Immunology, Vol. 27, No. 3, 1977, p. 512-515.

Research output: Contribution to journalArticle

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