Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin

Eszter Baltás, V. Trach, A. Dobozy, L. Kemény

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

It has been suggested that platelet-activating factor (PAF) plays a role in the pathomechanisms of various inflammatory diseases. In an experimental animal model we demonstrated earlier that a selective PAF receptor antagonist gel inhibits ultraviolet-B (UVB) light-induced edema in mouse ears. The goal of our present investigation was to determine whether locally applied WEB 2086, a selective PAF receptor antagonist, alters the dermatitis-causing effect of UVB light on human skin. We induced dermatitis in healthy volunteers by irradiating their skin with UVB light in increasing doses. The irradiated area was treated with WEB 2086 gel (3%) or with a placebo. Erythema was measured spectrophotometrically after 24 and 48 h. After both 24 and 48 h, the WEB 2086 gel significantly inhibited the UVB light-induced erythema each radiation dose in comparison with the placebo. The PAF antagonist gel therefore proved to be effective against UVB-induced dermatitis. Our results may help to under stand the relative importance of mediators UVB-induced dermatitis and might perhaps pave the way to better therapeutic modalities in this condition.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalSkin Pharmacology and Applied Skin Physiology
Volume16
Issue number4
DOIs
Publication statusPublished - Jun 12 2003

Keywords

  • Dermatitis
  • Platelet-activating factor
  • Ultraviolet light

ASJC Scopus subject areas

  • Dermatology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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