Approximate analysis of current-time transients in the Kval+ion-carrier system can be done for short- and long-time responses. The whole transport problem is nonlinear, but good approximations are possible for fixed-site membranes. A unique value of Dval, calculated from short- and from long-time data, agrees with the steady-state value already reported. There is no evidence for K+hopping; motion of Kval+from fixed site-to-site with back diffusion of free valinomycin is sufficient to explain transient and steady-state responses.
ASJC Scopus subject areas
- Analytical Chemistry