Plasmoblastic lymphoma associated with Human Immunodeficiency Virus

Emoke Horváth, L. Krenács, Eniko Bagdi, Z. Pávai, I. Macarie, Elod Erno Nagy, Smaranda Demian

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Plasmoblastic lymphoma (PBL) is a subtype of the diffuse large B-cell lymphoma, typically present as extranodal disease associated with human immune deficiency virus (HIV) infection. PBLs are often the initial manifestation of AIDS. Here we present a case of PBL concerning the oral cavity. A 34-year-old woman presented a tumor in the oral cavity that involved the maxilla and gingiva (confirmed by CT-scan). The gingival biopsy showed a massive infiltration by large lymphoid cells with round, vesicular nuclei, prominent nucleoli, fine chromatin and an significant amount of basophilic cytoplasm which express CD79a, CD138, cytoplasmic lambda light chain and LCA, without staining for CD20, CD38, CD3 and CTK. Serological analysis confirmed HIV positivity. PBLs lack most B-lineage markers, but many express CD79a in at least some of the cells, therefore generate difficulties in differential diagnosis. Overall assessment and correlation of the histopathological and immunohistochemical features with the clinical findings and serology investigation are the most helpful diagnostic tools and can lead to the final diagnosis.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalRomanian Journal of Morphology and Embryology
Volume49
Issue number3
Publication statusPublished - Dec 1 2008

    Fingerprint

Keywords

  • B-lineage markers
  • Extranodal PBL
  • HIV
  • Immunohistochemistry

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Embryology
  • Developmental Biology
  • Cell Biology

Cite this

Horváth, E., Krenács, L., Bagdi, E., Pávai, Z., Macarie, I., Nagy, E. E., & Demian, S. (2008). Plasmoblastic lymphoma associated with Human Immunodeficiency Virus. Romanian Journal of Morphology and Embryology, 49(3), 309-314.