Plasminogen activator inhibitors in human tears

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Plasminogen activator inhibitor activity was demonstrated in tears of patients suffering from various corneal and conjuntival diseases. Active plasminogen activator inhibitor was also detected by reverse fibrin zymography in tears of a patient suffering from Sjogren's syndrome and in those who underwent eye surgery. Immunoblotting revealed that both type 1 and type 2 plasminogen activator inhibitors may be present in human tears when the epithelial cells of the cornea and conjunctiva are affected and/or the permeability of the conjunctival blood vessels is increased. The molecular weight of inhibitors suggested the simultaneous presence of both free and activator-complexed inhibitors. However, no plasminogen activator inhibitor was detectable in normal human tears, suggesting that the presence of plasminogen activator inhibitors in tears may be associated with the pathological events at the ocular surface.

Original languageEnglish
Pages (from-to)426-431
Number of pages6
JournalActa Ophthalmologica
Volume69
Issue number4
Publication statusPublished - 1991

Fingerprint

Plasminogen Inactivators
Tears
Plasminogen Activator Inhibitor 2
Corneal Diseases
Conjunctiva
Sjogren's Syndrome
Plasminogen Activator Inhibitor 1
Fibrin
Psychological Stress
Immunoblotting
Cornea
Blood Vessels
Permeability
Molecular Weight
Epithelial Cells

Keywords

  • chromogenic assay
  • immunoblotting
  • inflammation
  • plasminogen activator inhibitors type 1 and 2
  • Sjogren's syndrome
  • tears

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Plasminogen activator inhibitors in human tears. / Tőzsér, J.; Berta, A.

In: Acta Ophthalmologica, Vol. 69, No. 4, 1991, p. 426-431.

Research output: Contribution to journalArticle

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