Plasmid elimination and immunomodulation by 3-benzazepines in vitro

Noboru Motohashi, Masami Kawase, Setsuo Saito, Csilla Miskolci, Livia Berek, J. Molnár

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

For studying the mechanisms of biological activity on 3-benzazepines, antimicrobial effect F'lac plasmid elimination activity (a plasmid curing effect on F'lac plasmid) and antibody-dependent cellular cytotoxicity (ADCC) test were performed. A weak antiplasmid effect was found at sub-inhibitory concentrations. A combination of [KF4] with verapamil [2] did not alter the ineffectivity, however, [KF4] could inhibit the antiplasmid effect of promethazine, as compared to the control (promethazine alone) plasmid curing effect A competition between promethazine and [KF4] might exist in plasmid elimination effect. ADCC activity of human leukocytes was enhanced by KF1, KF2, KF3, DA and NE at 1.0 μg/mL concentrations. The majority of 3-benzazepines [KS02, KM57, KN50, KE04, KI10, KP80] was ineffective for plasmid curing, however, inhibited the ADCC reaction, but they did not show a real dose-dependent effect.

Original languageEnglish
Pages (from-to)5075-5078
Number of pages4
JournalAnticancer Research
Volume19
Issue number6 B
Publication statusPublished - Nov 1999

Fingerprint

Benzazepines
Immunomodulation
Promethazine
Plasmids
F Factor
Antibodies
Verapamil
Human Activities
Leukocytes
In Vitro Techniques

Keywords

  • 3-Benzazepines
  • Plasmid elimination

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Motohashi, N., Kawase, M., Saito, S., Miskolci, C., Berek, L., & Molnár, J. (1999). Plasmid elimination and immunomodulation by 3-benzazepines in vitro. Anticancer Research, 19(6 B), 5075-5078.

Plasmid elimination and immunomodulation by 3-benzazepines in vitro. / Motohashi, Noboru; Kawase, Masami; Saito, Setsuo; Miskolci, Csilla; Berek, Livia; Molnár, J.

In: Anticancer Research, Vol. 19, No. 6 B, 11.1999, p. 5075-5078.

Research output: Contribution to journalArticle

Motohashi, N, Kawase, M, Saito, S, Miskolci, C, Berek, L & Molnár, J 1999, 'Plasmid elimination and immunomodulation by 3-benzazepines in vitro', Anticancer Research, vol. 19, no. 6 B, pp. 5075-5078.
Motohashi N, Kawase M, Saito S, Miskolci C, Berek L, Molnár J. Plasmid elimination and immunomodulation by 3-benzazepines in vitro. Anticancer Research. 1999 Nov;19(6 B):5075-5078.
Motohashi, Noboru ; Kawase, Masami ; Saito, Setsuo ; Miskolci, Csilla ; Berek, Livia ; Molnár, J. / Plasmid elimination and immunomodulation by 3-benzazepines in vitro. In: Anticancer Research. 1999 ; Vol. 19, No. 6 B. pp. 5075-5078.
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