Plasma‐membrane‐Bound mcromoleculas are dynamically aggregated to form non‐random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?

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Abstract

Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane‐bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin‐2 receptor, the T‐cell receptor–CD3 system, the intercellular adhesion molecule ICAM‐1, and the major histocompatilibilty complex class I and II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of icon channel activities, adduced as one of the major regulatory mechanisms of cell–cell communications. A general role in the mediation and regulation of intercellular interactions is suggested for cell‐surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accomodation and recognition processes at the cellular level.

Original languageEnglish
Pages (from-to)237-246
Number of pages10
JournalJournal of Molecular Recognition
Volume8
Issue number4
DOIs
Publication statusPublished - Jan 1 1995

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Keywords

  • MHC
  • antigen presentation
  • cell surface
  • energy transfer
  • flow cytometry
  • fluorescence
  • intercellular communication
  • intercellular communication
  • molecular pattern
  • transmembrane potential

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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