Plasma pepsinogen and adrenocortical activity - New data on the relationship

V. Varró, I. Faredin, L. Csernay

Research output: Contribution to journalArticle

Abstract

1. In the course of experiments on total gastrectomized dogs we have provided sufficient evidence that the pepsinogen demonstrable in blood is of gastric origin. 2. The increased plasma pepsinogen level due to a single ACTH stimulus may be evidenced in dogs also, provided determinations are made of the gastric venous blood. The examination of peripheral blood in the dog is not sufficiently informative, for the rise of the renal pepsinogen clearance following ACTH administration has a stabilizing effect on the pepsinogen level in the systemic circulation, frequently even reducing it. 3. In contrast to plasma pepsinogen changes observed previously in dogs with intact adrenals, no significant changes were demonstrable in adrenalectomized animals during development of experimental gastric ulcer.

Original languageEnglish
Pages (from-to)466-472
Number of pages7
JournalThe American Journal of Digestive Diseases
Volume5
Issue number5
DOIs
Publication statusPublished - May 1960

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Pepsinogen A
Dogs
Adrenocorticotropic Hormone
Stomach
Stomach Ulcer
Kidney

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Plasma pepsinogen and adrenocortical activity - New data on the relationship. / Varró, V.; Faredin, I.; Csernay, L.

In: The American Journal of Digestive Diseases, Vol. 5, No. 5, 05.1960, p. 466-472.

Research output: Contribution to journalArticle

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