Plasma nociceptin/orphanin FQ levels are lower in patients with chronic ischemic cardiovascular diseases-A pilot study

Miklós Krepuska, P. Sótónyi, Csaba Csobay-Novák, Zoltán Szeberin, István Hartyánszky, E. Zima, N. Szilágyi, F. Horkay, B. Merkely, G. Acsády, K. Tekes

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Clinical studies are limited regarding the role of human nociceptin/orphanin FQ (N/OFQ) in ischemic cardiovascular diseases, which are still the number one cause of death in the developed world. The aim of our study was to measure the plasma levels of N/OFQ in patients with chronic ischemic cardiovascular diseases in a pilot study. Methods and results: Our study population consisted of 22 patients presenting symptoms of stable angina pectoris (SAP): 12 severe Canadian Cardiovascular Society (CCS) III-IV functional class, and 10 with milder SAP (CCS II-III). 12 patients were also enrolled with chronic peripheral artery disease (9 with intermittent claudication; 3 with rest pain and gangrene). Patients were asked to avoid any exertion or given analgetics for their rest pain. Patients had no episodes of chest or limb pain in 1. week before their fasting blood samples were taken and N/OFQ plasma levels were measured by radioimmunoassay. 14 healthy subjects without any cardiac risk factors served as a control group. Conclusions: N/OFQ levels were significantly lower in patient groups with severe vs. milder chronic angina (p <0.05) and vs. control subjects (p <0.01). Patients suffering from peripheral artery disease had also a lower plasma N/OFQ levels than in healthy controls (p <0.01). Our findings show that chronic ischemic conditions of atherosclerotic origin are associated with significantly lower plasma N/OFQ levels.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalRegulatory Peptides
Volume169
Issue number1-3
DOIs
Publication statusPublished - Aug 8 2011

Fingerprint

Cardiovascular Diseases
Plasmas
Stable Angina
Peripheral Arterial Disease
Pain
Intermittent Claudication
Gangrene
nociceptin
Blood
Radioimmunoassay
Cause of Death
Fasting
Healthy Volunteers
Thorax
Extremities
Control Groups
Population

Keywords

  • Angina pectoris
  • Aortic valve stenosis
  • Coronary stenosis
  • Nociceptin/orphanin FQ
  • Peripheral artery disease

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Plasma nociceptin/orphanin FQ levels are lower in patients with chronic ischemic cardiovascular diseases-A pilot study. / Krepuska, Miklós; Sótónyi, P.; Csobay-Novák, Csaba; Szeberin, Zoltán; Hartyánszky, István; Zima, E.; Szilágyi, N.; Horkay, F.; Merkely, B.; Acsády, G.; Tekes, K.

In: Regulatory Peptides, Vol. 169, No. 1-3, 08.08.2011, p. 1-5.

Research output: Contribution to journalArticle

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AU - Krepuska, Miklós

AU - Sótónyi, P.

AU - Csobay-Novák, Csaba

AU - Szeberin, Zoltán

AU - Hartyánszky, István

AU - Zima, E.

AU - Szilágyi, N.

AU - Horkay, F.

AU - Merkely, B.

AU - Acsády, G.

AU - Tekes, K.

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KW - Peripheral artery disease

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