Plasma membrane Ca2+ ATPases as dynamic regulators of cellular calcium handling

Emanuel E. Strehler, Ariel J. Caride, Adelaida G. Filoteo, Yuning Xiong, John T. Penniston, A. Enyedi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

88 Citations (Scopus)

Abstract

Plasma membrane Ca2+ ATPases (PMCAs) are essential components of the cellular toolkit to regulate and fine-tune cytosolic Ca2+ concentrations. Historically, the PMCAs have been assigned a housekeeping role in the maintenance of intracellular Ca2+ homeostasis. More recent work has revealed a perplexing multitude of PMCA isoforms and alternative splice variants, raising questions about their specific role in Ca2+ handling under conditions of varying Ca2+ loads. Studies on the kinetics of individual isoforms, combined with expression and localization studies suggest that PMCAs are optimized to function in Ca2+ regulation according to tissue- and cell-specific demands. Different PMCA isoforms help control slow, tonic Ca2+ signals in some cells and rapid, efficient Ca2+ extrusion in others. Localized Ca2+ handling requires targeting of the pumps to specialized cellular locales, such as the apical membrane of cochlear hair cells or the basolateral membrane of kidney epithelial cells. Recent studies suggest that alternatively spliced regions in the PMCAs are responsible for their unique targeting, membrane localization, and signaling cross-talk. The regulated deployment and retrieval of PMCAs from specific membranes provide a dynamic system for a cell to respond to changing needs of Ca2+ regulation.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages226-236
Number of pages11
Volume1099
DOIs
Publication statusPublished - Mar 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1099
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Calcium-Transporting ATPases
Cell membranes
Cell Membrane
Calcium
Membranes
Protein Isoforms
Auditory Hair Cells
Housekeeping
Extrusion
Dynamical systems
Homeostasis
Epithelial Cells
Cells
Maintenance
Pumps
Tissue
Kidney
Kinetics

Keywords

  • Calcium homeostasis
  • Calcium pump
  • Calcium signaling
  • PMCA
  • Splice variant

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Strehler, E. E., Caride, A. J., Filoteo, A. G., Xiong, Y., Penniston, J. T., & Enyedi, A. (2007). Plasma membrane Ca2+ ATPases as dynamic regulators of cellular calcium handling. In Annals of the New York Academy of Sciences (Vol. 1099, pp. 226-236). (Annals of the New York Academy of Sciences; Vol. 1099). https://doi.org/10.1196/annals.1387.023

Plasma membrane Ca2+ ATPases as dynamic regulators of cellular calcium handling. / Strehler, Emanuel E.; Caride, Ariel J.; Filoteo, Adelaida G.; Xiong, Yuning; Penniston, John T.; Enyedi, A.

Annals of the New York Academy of Sciences. Vol. 1099 2007. p. 226-236 (Annals of the New York Academy of Sciences; Vol. 1099).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Strehler, EE, Caride, AJ, Filoteo, AG, Xiong, Y, Penniston, JT & Enyedi, A 2007, Plasma membrane Ca2+ ATPases as dynamic regulators of cellular calcium handling. in Annals of the New York Academy of Sciences. vol. 1099, Annals of the New York Academy of Sciences, vol. 1099, pp. 226-236. https://doi.org/10.1196/annals.1387.023
Strehler EE, Caride AJ, Filoteo AG, Xiong Y, Penniston JT, Enyedi A. Plasma membrane Ca2+ ATPases as dynamic regulators of cellular calcium handling. In Annals of the New York Academy of Sciences. Vol. 1099. 2007. p. 226-236. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1387.023
Strehler, Emanuel E. ; Caride, Ariel J. ; Filoteo, Adelaida G. ; Xiong, Yuning ; Penniston, John T. ; Enyedi, A. / Plasma membrane Ca2+ ATPases as dynamic regulators of cellular calcium handling. Annals of the New York Academy of Sciences. Vol. 1099 2007. pp. 226-236 (Annals of the New York Academy of Sciences).
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