Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits

Z. Jambrik, Mariann Gyöngyösi, P. Hegyi, L. Czakó, T. Takács, A. Farkas, Yvette Mándy, Csaba Góg, Dietmar Glogar, M. Csanády

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To examine the relationship between plasma cytokine levels and cardiac and hemodynamic function. Design: Measurement of cytokines and the systolic (left ventricular dimensions, heart rate, and cardiac output) and diastolic (early and late transmitral peak flow velocity: E and A-waves and their ratio) functions of the left ventricle (assessed by echocardiography) in rabbits. Setting and interventions: Laboratory and echocardiographic analyses were performed at baseline and at 1, 3, 6, 12, and 24 h after acute necrotizing pancreatitis induction (Group ANP), in rabbits aftersomatostatin pretreatment (Group S-ANP) and in sham-operated controls (Group C). Measurements and results: Left ventricular dilatation occurred at 6 h and cardiac output was increased 3 h after induction of acute necrotizing pancreatitis. Somatostatin pretreatment mitigated the left ventricular enlargement and filling abnormalities. Plasma level of IL-6 was increased significantly 3 h after pancreatitis induction, but to a lesser extent in Group S-ANP, while somatostatin prevented TNFa release (IL-6: Group ANP: 0, 0, 518±139, 956±125, 373±48, and 122±37 pg/ml; Group S-ANP: 0, 0, 191±68, 261±49, 23±13, and 0 pg/ml; TNFα: Group ANP: 88±42, 371±40, 2963±291, 276±30, 197±106, and 23±14 U/l; Group S-ANP: 91±34, 41±25, 68±42, 25±9, 0, and 0 U/ml). The increase in plasma level of IL-6 correlated significantly with left ventricular end-diastolic diameter and volume, cardiac output, and diastolic dysfunction. Conclusions: Plasma levels of IL-6, but not TNFα correlate with cardiac output and left ventricular filling characteristics in acute pancreatitis. Somatostatin pretreatment improves the cardiac and hemodynamic changes, probably through the decrease in cytokine release.

Original languageEnglish
Pages (from-to)1810-1818
Number of pages9
JournalIntensive Care Medicine
Volume28
Issue number12
DOIs
Publication statusPublished - 2002

Fingerprint

Atrial Natriuretic Factor
Pancreatitis
Interleukin-6
Hemodynamics
Rabbits
Cardiac Output
Somatostatin
Acute Necrotizing Pancreatitis
Cytokines
Stroke Volume
Heart Ventricles
Echocardiography
Dilatation
Heart Rate
Control Groups

Keywords

  • Acute pancreatitis
  • Hemodynamic abnormalities
  • IL-6
  • Plasma levels
  • Rabbits

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits. / Jambrik, Z.; Gyöngyösi, Mariann; Hegyi, P.; Czakó, L.; Takács, T.; Farkas, A.; Mándy, Yvette; Góg, Csaba; Glogar, Dietmar; Csanády, M.

In: Intensive Care Medicine, Vol. 28, No. 12, 2002, p. 1810-1818.

Research output: Contribution to journalArticle

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abstract = "Objective: To examine the relationship between plasma cytokine levels and cardiac and hemodynamic function. Design: Measurement of cytokines and the systolic (left ventricular dimensions, heart rate, and cardiac output) and diastolic (early and late transmitral peak flow velocity: E and A-waves and their ratio) functions of the left ventricle (assessed by echocardiography) in rabbits. Setting and interventions: Laboratory and echocardiographic analyses were performed at baseline and at 1, 3, 6, 12, and 24 h after acute necrotizing pancreatitis induction (Group ANP), in rabbits aftersomatostatin pretreatment (Group S-ANP) and in sham-operated controls (Group C). Measurements and results: Left ventricular dilatation occurred at 6 h and cardiac output was increased 3 h after induction of acute necrotizing pancreatitis. Somatostatin pretreatment mitigated the left ventricular enlargement and filling abnormalities. Plasma level of IL-6 was increased significantly 3 h after pancreatitis induction, but to a lesser extent in Group S-ANP, while somatostatin prevented TNFa release (IL-6: Group ANP: 0, 0, 518±139, 956±125, 373±48, and 122±37 pg/ml; Group S-ANP: 0, 0, 191±68, 261±49, 23±13, and 0 pg/ml; TNFα: Group ANP: 88±42, 371±40, 2963±291, 276±30, 197±106, and 23±14 U/l; Group S-ANP: 91±34, 41±25, 68±42, 25±9, 0, and 0 U/ml). The increase in plasma level of IL-6 correlated significantly with left ventricular end-diastolic diameter and volume, cardiac output, and diastolic dysfunction. Conclusions: Plasma levels of IL-6, but not TNFα correlate with cardiac output and left ventricular filling characteristics in acute pancreatitis. Somatostatin pretreatment improves the cardiac and hemodynamic changes, probably through the decrease in cytokine release.",
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T1 - Plasma levels of IL-6 correlate with hemodynamic abnormalities in acute pancreatitis in rabbits

AU - Jambrik, Z.

AU - Gyöngyösi, Mariann

AU - Hegyi, P.

AU - Czakó, L.

AU - Takács, T.

AU - Farkas, A.

AU - Mándy, Yvette

AU - Góg, Csaba

AU - Glogar, Dietmar

AU - Csanády, M.

PY - 2002

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N2 - Objective: To examine the relationship between plasma cytokine levels and cardiac and hemodynamic function. Design: Measurement of cytokines and the systolic (left ventricular dimensions, heart rate, and cardiac output) and diastolic (early and late transmitral peak flow velocity: E and A-waves and their ratio) functions of the left ventricle (assessed by echocardiography) in rabbits. Setting and interventions: Laboratory and echocardiographic analyses were performed at baseline and at 1, 3, 6, 12, and 24 h after acute necrotizing pancreatitis induction (Group ANP), in rabbits aftersomatostatin pretreatment (Group S-ANP) and in sham-operated controls (Group C). Measurements and results: Left ventricular dilatation occurred at 6 h and cardiac output was increased 3 h after induction of acute necrotizing pancreatitis. Somatostatin pretreatment mitigated the left ventricular enlargement and filling abnormalities. Plasma level of IL-6 was increased significantly 3 h after pancreatitis induction, but to a lesser extent in Group S-ANP, while somatostatin prevented TNFa release (IL-6: Group ANP: 0, 0, 518±139, 956±125, 373±48, and 122±37 pg/ml; Group S-ANP: 0, 0, 191±68, 261±49, 23±13, and 0 pg/ml; TNFα: Group ANP: 88±42, 371±40, 2963±291, 276±30, 197±106, and 23±14 U/l; Group S-ANP: 91±34, 41±25, 68±42, 25±9, 0, and 0 U/ml). The increase in plasma level of IL-6 correlated significantly with left ventricular end-diastolic diameter and volume, cardiac output, and diastolic dysfunction. Conclusions: Plasma levels of IL-6, but not TNFα correlate with cardiac output and left ventricular filling characteristics in acute pancreatitis. Somatostatin pretreatment improves the cardiac and hemodynamic changes, probably through the decrease in cytokine release.

AB - Objective: To examine the relationship between plasma cytokine levels and cardiac and hemodynamic function. Design: Measurement of cytokines and the systolic (left ventricular dimensions, heart rate, and cardiac output) and diastolic (early and late transmitral peak flow velocity: E and A-waves and their ratio) functions of the left ventricle (assessed by echocardiography) in rabbits. Setting and interventions: Laboratory and echocardiographic analyses were performed at baseline and at 1, 3, 6, 12, and 24 h after acute necrotizing pancreatitis induction (Group ANP), in rabbits aftersomatostatin pretreatment (Group S-ANP) and in sham-operated controls (Group C). Measurements and results: Left ventricular dilatation occurred at 6 h and cardiac output was increased 3 h after induction of acute necrotizing pancreatitis. Somatostatin pretreatment mitigated the left ventricular enlargement and filling abnormalities. Plasma level of IL-6 was increased significantly 3 h after pancreatitis induction, but to a lesser extent in Group S-ANP, while somatostatin prevented TNFa release (IL-6: Group ANP: 0, 0, 518±139, 956±125, 373±48, and 122±37 pg/ml; Group S-ANP: 0, 0, 191±68, 261±49, 23±13, and 0 pg/ml; TNFα: Group ANP: 88±42, 371±40, 2963±291, 276±30, 197±106, and 23±14 U/l; Group S-ANP: 91±34, 41±25, 68±42, 25±9, 0, and 0 U/ml). The increase in plasma level of IL-6 correlated significantly with left ventricular end-diastolic diameter and volume, cardiac output, and diastolic dysfunction. Conclusions: Plasma levels of IL-6, but not TNFα correlate with cardiac output and left ventricular filling characteristics in acute pancreatitis. Somatostatin pretreatment improves the cardiac and hemodynamic changes, probably through the decrease in cytokine release.

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KW - Hemodynamic abnormalities

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KW - Plasma levels

KW - Rabbits

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