Plasma levels of beta-thromboglobulin and factor viii-related antigen in diabetic children and adults

K. Rak, P. Beck, M. Udvardy, G. Pfliegler, M. Misz, Z. Boda

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

In order to investigate the relationship between the in vivo platelet activation in diabetes mellitus and the endothelial damage connected with the diabetic micro- and/or macroangiopathy, plasma levels of beta-thromboglobulin (B-TG) and of factor VIII-related antigen (VIII R:Ag) were studied (1) in juvenile-onset (Type I) diabetics without clinical signs of angiopathy (age under 12 years) and (2) in mostly maturity-onset (Type II) diabetics with and without overt angiopathy (age between 14 and 60 years). Normal controls and nondiabetics with atherosclerosis were also studied. Plasma levels of both proteins were found to be elevated in all the groups of diabetic and atherosclerotic patients in comparison with the controls. Highest levels were found in adult diabetics with angiopathy and in atherosclerotics even without diabetes, but values of the diabetic children were also elevated. The data suggest a causal relationship between the vascular damage and the enhanced platelet reactivity in which the former may play the primary role.

Original languageEnglish
Pages (from-to)155-162
Number of pages8
JournalThrombosis Research
Volume29
Issue number2
DOIs
Publication statusPublished - Jan 15 1983

Fingerprint

beta-Thromboglobulin
Antigens
Diabetic Angiopathies
Platelet Activation
von Willebrand Factor
Blood Vessels
Atherosclerosis
Diabetes Mellitus
Blood Platelets
Proteins

Keywords

  • atherosclerosis
  • beta-thromboglobulin
  • diabetes mellitus
  • diabetic angiopathy
  • factor VIII-related antigen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

Cite this

Plasma levels of beta-thromboglobulin and factor viii-related antigen in diabetic children and adults. / Rak, K.; Beck, P.; Udvardy, M.; Pfliegler, G.; Misz, M.; Boda, Z.

In: Thrombosis Research, Vol. 29, No. 2, 15.01.1983, p. 155-162.

Research output: Contribution to journalArticle

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AU - Misz, M.

AU - Boda, Z.

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