Plasma levels of asymmetric dimethylarginine in premature neonates: Its possible involvement in developmental programming of chronic diseases

Gabriella Vida, E. Sulyok, Orsolya Lakatos, Tibor Ertl, Jens Martens-Lobenhoffer, Stefanie M. Bode-Böger

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Aim: The endothel dysfunction in early life may play a role in developmental programming of cardiovascular morbidity. The changes of dimethylarginines' plasma levels during the first month among preterm infants and their determinants had been investigated in our study. Methods: Twenty preterm infants of healthy mothers were studied. Mean (±SD) birth weight and gestational age were 919.5 ± 235.5 g and 26.7 ± 1.6 weeks, respectively. Blood samples were taken by venipuncture at the 3rd, 7th, 14th, 21st and 28th days. Plasma concentrations of L-arginine, asymmetric and symmetric dimethylarginine (SDMA) were measured by liquid chromatography-mass spectrometry method, evaluated by multivariate linear regression analysis. Results: L-arginine (p <0.001) and asymmetric dimethylarginine (ADMA) levels (p <0.001) were positively associated with postnatal age. ADMA levels were negatively correlated with gestational age (p = 0.007), dopamine-need on the 3rd day of life (p = 0.015) and late infection (p = 0.038). The higher birth weight was associated with higher L-arginine (p = 0.052) and ADMA (p = 0.002) concentrations. The dopamine-need on the 7th day of life had a significant effect on postnatal elevation of SDMA levels (p = 0.035). Conclusion: The progressive increase of ADMA levels described by our study among preterm infants suggests that early endothel dysfunction may take part in developmental programming of chronic adult diseases.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Volume98
Issue number3
DOIs
Publication statusPublished - Mar 2009

Fingerprint

Chronic Disease
Newborn Infant
Premature Infants
Arginine
Birth Weight
Gestational Age
Dopamine
Phlebotomy
Liquid Chromatography
Linear Models
Mass Spectrometry
Regression Analysis
Mothers
N,N-dimethylarginine
Morbidity
Infection
N,N'-dimethylarginine

Keywords

  • Asymmetric dimethylarginine
  • Developmental programming
  • Endothel dysfunction
  • Prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Plasma levels of asymmetric dimethylarginine in premature neonates : Its possible involvement in developmental programming of chronic diseases. / Vida, Gabriella; Sulyok, E.; Lakatos, Orsolya; Ertl, Tibor; Martens-Lobenhoffer, Jens; Bode-Böger, Stefanie M.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 98, No. 3, 03.2009, p. 437-441.

Research output: Contribution to journalArticle

Vida, Gabriella ; Sulyok, E. ; Lakatos, Orsolya ; Ertl, Tibor ; Martens-Lobenhoffer, Jens ; Bode-Böger, Stefanie M. / Plasma levels of asymmetric dimethylarginine in premature neonates : Its possible involvement in developmental programming of chronic diseases. In: Acta Paediatrica, International Journal of Paediatrics. 2009 ; Vol. 98, No. 3. pp. 437-441.
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