Plasma levels of acylated ghrelin during an oral glucose tolerance test in obese children

Eva Lányi, K. Csernus, E. Erhardt, K. Tóth, B. Urbán, L. Lénárd, D. Molnár

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Ghrelin is an acylated peptide with octanoyl modification, which is essential for its GH-releasing ability. Coexpression of GH secretagogue receptor (GHS-R) and ghrelin in the pancreas suggests that this peptide is involved in glucose metabolism. The other form of the molecule, the non-acylated ghrelin, has been reported to be devoid of any pituitaric endocrine activities. Previous reports demonstrated that plasma total ghrelin levels decrease after oral glucose administration in obese children, but no data are available about the plasma levels of acylated ghrelin. Therefore, in the present study the plasma levels of acylated ghrelin were measured in obese and control children during oral glucose tolerance test (OGTT). Materials and methods: Acylated ghrelin response to OGTT was evaluated in 11 obese and 9 age-matched control children. All subjects received 0.75 g/kg (maximum 75 g) glucose solution orally after an overnight fast. Acylated ghrelin, insulin, glucose, and GH were determined at 0, 30, 60 and 120 min, and leptin at 0 min of the OGTT. Results: Plasma basal levels of acylated ghrelin were significantly lower in the obese children than in the controls (66.3±6.7 vs 97.2±14.4 pg/ml, p

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalJournal of Endocrinological Investigation
Volume30
Issue number2
Publication statusPublished - Feb 2007

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Ghrelin
Glucose Tolerance Test
Glucose
Ghrelin Receptor
Peptides
Leptin
Oral Administration
Pancreas
Insulin

Keywords

  • Acylated ghrelin
  • Obese children

ASJC Scopus subject areas

  • Endocrinology

Cite this

Plasma levels of acylated ghrelin during an oral glucose tolerance test in obese children. / Lányi, Eva; Csernus, K.; Erhardt, E.; Tóth, K.; Urbán, B.; Lénárd, L.; Molnár, D.

In: Journal of Endocrinological Investigation, Vol. 30, No. 2, 02.2007, p. 133-137.

Research output: Contribution to journalArticle

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AU - Lányi, Eva

AU - Csernus, K.

AU - Erhardt, E.

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AU - Urbán, B.

AU - Lénárd, L.

AU - Molnár, D.

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