Plasma hyaluronan concentration

No circadian rhythm but large effect of food intake in humans

Andreas Rössler, Z. László, Erich Kvas, Helmut G. Hinghofer-Szalkay

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

This study was designed to determine if a circadian rhythm in plasma hyaluronan concentration [HA] exists in the absence of physical activity, and if plasma [HA] is associated with feeding in human subjects. Five persons were studied under standardized conditions, blood samples being taken between 0600 and 2200 hours at 30-min intervals. Any orthostatic challenge and muscle activity was abolished by immobilization by a 6°head-down bed-rest, and the effect of a quasi-continuous ingestion of energy compared a normal, three-portion diet of equivalent energy content or to fasting. Reproducibility of HA profiles on two consecutive half-days was also studied. A highly sensitive immunoassay was used to determine plasma [HA]. The data indicated that without physical activity and without food ingestion, [HA] was unchanged and displayed no diurnal rhythm. In addition, we observed that [HA] increased after the first food intake, peaking after 60 min, and concluded from our results that without ingestion of a larger meal, and sessions of postural or muscle activity no circadian plasma [HA] rhythm exists.

Original languageEnglish
Pages (from-to)573-577
Number of pages5
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Volume78
Issue number6
DOIs
Publication statusPublished - Nov 1998

Fingerprint

Hyaluronic Acid
Circadian Rhythm
Eating
Muscles
Bed Rest
Immunoassay
Immobilization
Meals
Fasting
Diet
Food

Keywords

  • Bedrest
  • Circadian rhythm
  • Hyaluronan
  • Hyaluronic acid
  • Lymph flux

ASJC Scopus subject areas

  • Physiology
  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physiology (medical)

Cite this

Plasma hyaluronan concentration : No circadian rhythm but large effect of food intake in humans. / Rössler, Andreas; László, Z.; Kvas, Erich; Hinghofer-Szalkay, Helmut G.

In: European Journal of Applied Physiology and Occupational Physiology, Vol. 78, No. 6, 11.1998, p. 573-577.

Research output: Contribution to journalArticle

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