Plasma hyaluronan concentration: No circadian rhythm but large effect of food intake in humans

Andreas Rössler, Zoltán László, Erich Kvas, Helmut G. Hinghofer-Szalkay

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17 Citations (Scopus)


This study was designed to determine if a circadian rhythm in plasma hyaluronan concentration [HA] exists in the absence of physical activity, and if plasma [HA] is associated with feeding in human subjects. Five persons were studied under standardized conditions, blood samples being taken between 0600 and 2200 hours at 30-min intervals. Any orthostatic challenge and muscle activity was abolished by immobilization by a 6°head-down bed-rest, and the effect of a quasi-continuous ingestion of energy compared a normal, three-portion diet of equivalent energy content or to fasting. Reproducibility of HA profiles on two consecutive half-days was also studied. A highly sensitive immunoassay was used to determine plasma [HA]. The data indicated that without physical activity and without food ingestion, [HA] was unchanged and displayed no diurnal rhythm. In addition, we observed that [HA] increased after the first food intake, peaking after 60 min, and concluded from our results that without ingestion of a larger meal, and sessions of postural or muscle activity no circadian plasma [HA] rhythm exists.

Original languageEnglish
Pages (from-to)573-577
Number of pages5
JournalEuropean Journal of Applied Physiology and Occupational Physiology
Issue number6
Publication statusPublished - Nov 1 1998



  • Bedrest
  • Circadian rhythm
  • Hyaluronan
  • Hyaluronic acid
  • Lymph flux

ASJC Scopus subject areas

  • Physiology
  • Public Health, Environmental and Occupational Health

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