Plasma homocysteine levels are related to medium-term venous graft degeneration in coronary artery bypass graft patients

Emília Balogh, Tamás Maros, Andrea Daragó, Kálmán Csapó, Béla Herceg, Balázs Nyul, István Czuriga, Zsuzsanna Bereczky, I. Édes, Zsolt Kőszegi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Saphenous venous grafts (SVGs) are established choices for coronary artery bypass grafting (CABG); however, their lumen patency is limited. Our goal was to investigate the risk factors of SVG degeneration. Methods: Seventy-five patients (mean age, 57.5±10.4 years) with 133 SVG conduits who had cardiac catheterization ≥1 year after CABG were selected; follow-up period was 67.6±36.8 months. Patients were divided into 3 groups according to angiographic status at follow up [intact: <20% (n=23); narrowed: 20–99% (n=24); and occluded (n=28)]. Baseline clinical conditions were evaluated in relation to follow-up angiography. As onset date of chronic total occlusions is usually uncertain, they arise typically from thrombotic lesions; thus, their value in evaluation is limited. Results: There were no significant differences between the 3 groups in clinical parameters. Linear correlation analysis found significant (p<0.01) positive connection of SVG disease (luminal diameter reduction 20–99%) with C-reactive protein (CRP) and homocysteine (Hcy), as well as between CRP and Hcy. Multiple regression analysis showed plasma Hcy level to be significantly related to graft diameter reduction normalized to time elapsed until angiography in narrowed grafts: 1 μmol/L increase of Hcy was associated with 0.053%/month decrease in lumen diameter (p<0.01; R2=0.428); extrapolating: +10 μmol/L higher Hcy level during 5 years is associated with 32.1% lumen reduction. Conclusion: Medium- to long-term SVG degeneration is related to elevated plasma total Hcy in patients with sub-occlusive graft stenosis, while in cases with intact SVGs, the beneficial local flow conditions may protect the grafts from degeneration.

Original languageEnglish
Pages (from-to)868-873
Number of pages6
JournalAnatolian journal of cardiology
Volume16
Issue number11
DOIs
Publication statusPublished - 2016

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Tunica Media
Homocysteine
Coronary Artery Bypass
Transplants
C-Reactive Protein
Angiography
Cardiac Catheterization
Pathologic Constriction
Regression Analysis

Keywords

  • Homocysteine
  • Saphenous vein graft disease

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Plasma homocysteine levels are related to medium-term venous graft degeneration in coronary artery bypass graft patients. / Balogh, Emília; Maros, Tamás; Daragó, Andrea; Csapó, Kálmán; Herceg, Béla; Nyul, Balázs; Czuriga, István; Bereczky, Zsuzsanna; Édes, I.; Kőszegi, Zsolt.

In: Anatolian journal of cardiology, Vol. 16, No. 11, 2016, p. 868-873.

Research output: Contribution to journalArticle

Balogh, E, Maros, T, Daragó, A, Csapó, K, Herceg, B, Nyul, B, Czuriga, I, Bereczky, Z, Édes, I & Kőszegi, Z 2016, 'Plasma homocysteine levels are related to medium-term venous graft degeneration in coronary artery bypass graft patients', Anatolian journal of cardiology, vol. 16, no. 11, pp. 868-873. https://doi.org/10.14744/AnatolJCardiol.2016.6738
Balogh, Emília ; Maros, Tamás ; Daragó, Andrea ; Csapó, Kálmán ; Herceg, Béla ; Nyul, Balázs ; Czuriga, István ; Bereczky, Zsuzsanna ; Édes, I. ; Kőszegi, Zsolt. / Plasma homocysteine levels are related to medium-term venous graft degeneration in coronary artery bypass graft patients. In: Anatolian journal of cardiology. 2016 ; Vol. 16, No. 11. pp. 868-873.
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abstract = "Objective: Saphenous venous grafts (SVGs) are established choices for coronary artery bypass grafting (CABG); however, their lumen patency is limited. Our goal was to investigate the risk factors of SVG degeneration. Methods: Seventy-five patients (mean age, 57.5±10.4 years) with 133 SVG conduits who had cardiac catheterization ≥1 year after CABG were selected; follow-up period was 67.6±36.8 months. Patients were divided into 3 groups according to angiographic status at follow up [intact: <20{\%} (n=23); narrowed: 20–99{\%} (n=24); and occluded (n=28)]. Baseline clinical conditions were evaluated in relation to follow-up angiography. As onset date of chronic total occlusions is usually uncertain, they arise typically from thrombotic lesions; thus, their value in evaluation is limited. Results: There were no significant differences between the 3 groups in clinical parameters. Linear correlation analysis found significant (p<0.01) positive connection of SVG disease (luminal diameter reduction 20–99{\%}) with C-reactive protein (CRP) and homocysteine (Hcy), as well as between CRP and Hcy. Multiple regression analysis showed plasma Hcy level to be significantly related to graft diameter reduction normalized to time elapsed until angiography in narrowed grafts: 1 μmol/L increase of Hcy was associated with 0.053{\%}/month decrease in lumen diameter (p<0.01; R2=0.428); extrapolating: +10 μmol/L higher Hcy level during 5 years is associated with 32.1{\%} lumen reduction. Conclusion: Medium- to long-term SVG degeneration is related to elevated plasma total Hcy in patients with sub-occlusive graft stenosis, while in cases with intact SVGs, the beneficial local flow conditions may protect the grafts from degeneration.",
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T1 - Plasma homocysteine levels are related to medium-term venous graft degeneration in coronary artery bypass graft patients

AU - Balogh, Emília

AU - Maros, Tamás

AU - Daragó, Andrea

AU - Csapó, Kálmán

AU - Herceg, Béla

AU - Nyul, Balázs

AU - Czuriga, István

AU - Bereczky, Zsuzsanna

AU - Édes, I.

AU - Kőszegi, Zsolt

PY - 2016

Y1 - 2016

N2 - Objective: Saphenous venous grafts (SVGs) are established choices for coronary artery bypass grafting (CABG); however, their lumen patency is limited. Our goal was to investigate the risk factors of SVG degeneration. Methods: Seventy-five patients (mean age, 57.5±10.4 years) with 133 SVG conduits who had cardiac catheterization ≥1 year after CABG were selected; follow-up period was 67.6±36.8 months. Patients were divided into 3 groups according to angiographic status at follow up [intact: <20% (n=23); narrowed: 20–99% (n=24); and occluded (n=28)]. Baseline clinical conditions were evaluated in relation to follow-up angiography. As onset date of chronic total occlusions is usually uncertain, they arise typically from thrombotic lesions; thus, their value in evaluation is limited. Results: There were no significant differences between the 3 groups in clinical parameters. Linear correlation analysis found significant (p<0.01) positive connection of SVG disease (luminal diameter reduction 20–99%) with C-reactive protein (CRP) and homocysteine (Hcy), as well as between CRP and Hcy. Multiple regression analysis showed plasma Hcy level to be significantly related to graft diameter reduction normalized to time elapsed until angiography in narrowed grafts: 1 μmol/L increase of Hcy was associated with 0.053%/month decrease in lumen diameter (p<0.01; R2=0.428); extrapolating: +10 μmol/L higher Hcy level during 5 years is associated with 32.1% lumen reduction. Conclusion: Medium- to long-term SVG degeneration is related to elevated plasma total Hcy in patients with sub-occlusive graft stenosis, while in cases with intact SVGs, the beneficial local flow conditions may protect the grafts from degeneration.

AB - Objective: Saphenous venous grafts (SVGs) are established choices for coronary artery bypass grafting (CABG); however, their lumen patency is limited. Our goal was to investigate the risk factors of SVG degeneration. Methods: Seventy-five patients (mean age, 57.5±10.4 years) with 133 SVG conduits who had cardiac catheterization ≥1 year after CABG were selected; follow-up period was 67.6±36.8 months. Patients were divided into 3 groups according to angiographic status at follow up [intact: <20% (n=23); narrowed: 20–99% (n=24); and occluded (n=28)]. Baseline clinical conditions were evaluated in relation to follow-up angiography. As onset date of chronic total occlusions is usually uncertain, they arise typically from thrombotic lesions; thus, their value in evaluation is limited. Results: There were no significant differences between the 3 groups in clinical parameters. Linear correlation analysis found significant (p<0.01) positive connection of SVG disease (luminal diameter reduction 20–99%) with C-reactive protein (CRP) and homocysteine (Hcy), as well as between CRP and Hcy. Multiple regression analysis showed plasma Hcy level to be significantly related to graft diameter reduction normalized to time elapsed until angiography in narrowed grafts: 1 μmol/L increase of Hcy was associated with 0.053%/month decrease in lumen diameter (p<0.01; R2=0.428); extrapolating: +10 μmol/L higher Hcy level during 5 years is associated with 32.1% lumen reduction. Conclusion: Medium- to long-term SVG degeneration is related to elevated plasma total Hcy in patients with sub-occlusive graft stenosis, while in cases with intact SVGs, the beneficial local flow conditions may protect the grafts from degeneration.

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KW - Saphenous vein graft disease

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