Plasma factors influencing prostacyclin-like activity in patients with diabetic microangiopathy

S. Túri, Marta Magyari, Marta Nemeth, Csaba Bereczky

Research output: Contribution to journalArticle

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Abstract

Plasma factors influencing PGI2-like activity in 19 patients with diabetes mellitus /Dm/ and 17 controls were studied through a comparison with the signs of retinal and glomerular angiopathy. The plasma PGI2 supporting activity /PSA/ was lower in 15 Dm cases than in the controls. Inhibitory activity against PGI2 production was detected in 6 patients. In the cases of more serious retinopathy associated with glomerulopathy, a significantly lower level of PSA was observed than in patients with mild retinopathy without glomerular diseases. The plasma concentrations of total and LDL-cholesterol were significantly higher, while the level of HDL-cholesterol was lower than in the controls. There was a positive correlation between PSA and HDL-cholesterol values and a negative correlation between PSA and LDL-cholesterol levels, which relates to an inhibitory effect of LDL and a protective role of HDL in PGI2 synthesis.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume31
Issue number3
DOIs
Publication statusPublished - 1988

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Diabetic Angiopathies
Epoprostenol
Thermodynamic properties
Plasmas
LDL Cholesterol
HDL Cholesterol
Medical problems
Diabetes Mellitus

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Physiology

Cite this

Plasma factors influencing prostacyclin-like activity in patients with diabetic microangiopathy. / Túri, S.; Magyari, Marta; Nemeth, Marta; Bereczky, Csaba.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 31, No. 3, 1988, p. 107-111.

Research output: Contribution to journalArticle

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