Plasma desorption mass spectrometry of haemoglobin tryptic peptides for the characterization of a Hungarian α-chain variant

O. Norregaard Jensen, P. Roepstorff, B. Rozynov, M. Horányi, J. Szelényi, S. Hollán, E. A. Aseeva, V. A. Spivak

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

S-Aminoethylated-α(A) and -β(A) globin tryptic peptides separated by reversed-phase high-performance liquid chromatography have been analysed by plasma desorption mass spectrometry. Almost all the expected α(A) and β(A) tryptic fragments were tentatively assigned relative to the known globin chain sequences based on the molecular weight obtained by plasma desorption mass spectrometric analysis of the purified peptides. The application of plasma desorption mass spectrometry for structure elucidation of a haemoglobin α-chain variant revealed the first case of Hb Hasharon in Hungary.

Original languageEnglish
Pages (from-to)579-584
Number of pages6
JournalBiological Mass Spectrometry
Volume20
Issue number10
Publication statusPublished - Oct 1991

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Mass spectrometry
Desorption
Mass Spectrometry
Hemoglobins
Globins
Plasmas
Peptides
Hungary
High performance liquid chromatography
Reverse-Phase Chromatography
Molecular Weight
Molecular weight
High Pressure Liquid Chromatography
hemoglobin Sealy

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Plasma desorption mass spectrometry of haemoglobin tryptic peptides for the characterization of a Hungarian α-chain variant. / Norregaard Jensen, O.; Roepstorff, P.; Rozynov, B.; Horányi, M.; Szelényi, J.; Hollán, S.; Aseeva, E. A.; Spivak, V. A.

In: Biological Mass Spectrometry, Vol. 20, No. 10, 10.1991, p. 579-584.

Research output: Contribution to journalArticle

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