Plasma cortisol, prolactin and thyroxine levels related to midazolam anaesthesia.

A. Kertész, G. Godó, G. Falkay, M. Boros

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Changes of plasma cortisol, prolactin and thyroxine levels as a result of surgical stress were examined in 11 patients undergoing abdominal hysterectomy. General anaesthesia was induced with the new benzodiazepine derivative midazolam (0.25 +/- 0.04 mg/kg) and maintained by nitrous oxide in oxygen. Plasma cortisol and thyroxine levels slightly decreased at the induction of anaesthesia and the beginning of surgery, while the prolactin level increased. By the end of surgery the cortisol and prolactin concentrations increased significantly, although the thyroxine level had barely changed. The highest hormone values were observed a few hours after the operation, but on the next morning hormone levels approached the normal range. On the basis of these results anaesthesia induction with midazolam can be said to have favourably affected the unwanted degree of hormonal changes related to surgery.

Original languageEnglish
Pages (from-to)283-289
Number of pages7
JournalActa Medica Hungarica
Volume43
Issue number3
Publication statusPublished - 1986

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Midazolam
Thyroxine
Prolactin
Hydrocortisone
Anesthesia
Hormones
Nitrous Oxide
Hysterectomy
Benzodiazepines
General Anesthesia
Reference Values
Oxygen

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Plasma cortisol, prolactin and thyroxine levels related to midazolam anaesthesia. / Kertész, A.; Godó, G.; Falkay, G.; Boros, M.

In: Acta Medica Hungarica, Vol. 43, No. 3, 1986, p. 283-289.

Research output: Contribution to journalArticle

Kertész, A. ; Godó, G. ; Falkay, G. ; Boros, M. / Plasma cortisol, prolactin and thyroxine levels related to midazolam anaesthesia. In: Acta Medica Hungarica. 1986 ; Vol. 43, No. 3. pp. 283-289.
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