Plasma corticosterone (CST) level and body weight were studied in male and female rats after bilateral pallidal lesion (GPL). The effect of a high dose of glycocorticoids on body weight of food and water-deprived, non-lesioned rats was also studied since high CST levels due to the stress caused by aphagia and adipsia could be anticipated. Weight changes in lesioned-adrenalectomized animals were investigated as well. A weight loss, higher in males than females, developed after the pallidal lesion and the CST level was higher in lesioned females than in lesioned males. This sex difference was present in non-lesioned, food and water-deprived animals as well. The weight loss was higher in lesioned males than in food and water-deprived male/female controls. Adrenalectomy eleminated weight loss differences between the sexes after lesion, by reducing the weight loss in males. CST administration reduced body weight loss in food and water deprived males but not in females, and cortisol facilitated it in both sexes.
|Number of pages||7|
|Journal||Acta physiologica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1979|
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