Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes

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Abstract

Crohn's disease (CD) is a chronic inflammatory bowel disorder caused by environmental and genetic factors. The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping for SLC22A4 1672C → T, SLC22A5-207G → C mutations and three common NOD2 variants (R702W, G908R and 1007finsC) were performed in 100 adult CD patients and in ninety-four healthy controls by direct sequencing. The carnitine ester profile was determined using ESI triple quadrupole tandem MS. Contrary to the NOD2/CARD15 mutations, none of the SLC variants showed increased prevalence in the CD group, the prevalence of TC haplotype did not differ between the patients and the controls. In the mixed group of CD patients the fasting propionyl-(0.243 (SEM 0.008) v. 0.283 (SEM 0.014) mmol/l), butyryl- (0.274 (SEM 0.009) v. 0.301 (SEM 0.013)) and isovalerylcarnitine (0.147 (SEM 0.006) v. 0.185 (SEM 0.009)) levels were decreased; while the level of octenoyl- (0.086 (SEM 0.006) v. 0.069 (SEM 0.005)), myristoleyl- (0.048 (SEM 0.003) v. 0.037 (SEM 0.003)), palmitoyl- (0.140 (SEM 0.005) v. 0.122 (SEM 0.004)) and oleylcarnitine (0.172 (SEM 0.006) v. 0.156 (SEM 0.008); P

Original languageEnglish
Pages (from-to)345-350
Number of pages6
JournalBritish Journal of Nutrition
Volume98
Issue number2
DOIs
Publication statusPublished - Aug 2007

Fingerprint

Carnitine
Crohn Disease
Esters
Genotype
Mutation
Haplotypes
Cations
Fasting
Genes

Keywords

  • Carnitine ester profile
  • Crohn's disease
  • NOD2/CARD15
  • OCTN1
  • OCTN2

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

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title = "Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes",
abstract = "Crohn's disease (CD) is a chronic inflammatory bowel disorder caused by environmental and genetic factors. The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping for SLC22A4 1672C → T, SLC22A5-207G → C mutations and three common NOD2 variants (R702W, G908R and 1007finsC) were performed in 100 adult CD patients and in ninety-four healthy controls by direct sequencing. The carnitine ester profile was determined using ESI triple quadrupole tandem MS. Contrary to the NOD2/CARD15 mutations, none of the SLC variants showed increased prevalence in the CD group, the prevalence of TC haplotype did not differ between the patients and the controls. In the mixed group of CD patients the fasting propionyl-(0.243 (SEM 0.008) v. 0.283 (SEM 0.014) mmol/l), butyryl- (0.274 (SEM 0.009) v. 0.301 (SEM 0.013)) and isovalerylcarnitine (0.147 (SEM 0.006) v. 0.185 (SEM 0.009)) levels were decreased; while the level of octenoyl- (0.086 (SEM 0.006) v. 0.069 (SEM 0.005)), myristoleyl- (0.048 (SEM 0.003) v. 0.037 (SEM 0.003)), palmitoyl- (0.140 (SEM 0.005) v. 0.122 (SEM 0.004)) and oleylcarnitine (0.172 (SEM 0.006) v. 0.156 (SEM 0.008); P",
keywords = "Carnitine ester profile, Crohn's disease, NOD2/CARD15, OCTN1, OCTN2",
author = "J. Bene and K. Koml{\'o}si and L. Magyari and G. Tali{\'a}n and Krisztina Horv{\'a}th and B. Gasztonyi and P. Miheller and M. Figler and G. M{\'o}zsik and Z. Tulassay and B. Melegh",
year = "2007",
month = "8",
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pages = "345--350",
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T1 - Plasma carnitine ester profiles in Crohn's disease patients characterized for SLC22A4 C1672T and SLC22A5 G-207C genotypes

AU - Bene, J.

AU - Komlósi, K.

AU - Magyari, L.

AU - Talián, G.

AU - Horváth, Krisztina

AU - Gasztonyi, B.

AU - Miheller, P.

AU - Figler, M.

AU - Mózsik, G.

AU - Tulassay, Z.

AU - Melegh, B.

PY - 2007/8

Y1 - 2007/8

N2 - Crohn's disease (CD) is a chronic inflammatory bowel disorder caused by environmental and genetic factors. The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping for SLC22A4 1672C → T, SLC22A5-207G → C mutations and three common NOD2 variants (R702W, G908R and 1007finsC) were performed in 100 adult CD patients and in ninety-four healthy controls by direct sequencing. The carnitine ester profile was determined using ESI triple quadrupole tandem MS. Contrary to the NOD2/CARD15 mutations, none of the SLC variants showed increased prevalence in the CD group, the prevalence of TC haplotype did not differ between the patients and the controls. In the mixed group of CD patients the fasting propionyl-(0.243 (SEM 0.008) v. 0.283 (SEM 0.014) mmol/l), butyryl- (0.274 (SEM 0.009) v. 0.301 (SEM 0.013)) and isovalerylcarnitine (0.147 (SEM 0.006) v. 0.185 (SEM 0.009)) levels were decreased; while the level of octenoyl- (0.086 (SEM 0.006) v. 0.069 (SEM 0.005)), myristoleyl- (0.048 (SEM 0.003) v. 0.037 (SEM 0.003)), palmitoyl- (0.140 (SEM 0.005) v. 0.122 (SEM 0.004)) and oleylcarnitine (0.172 (SEM 0.006) v. 0.156 (SEM 0.008); P

AB - Crohn's disease (CD) is a chronic inflammatory bowel disorder caused by environmental and genetic factors. The purpose of this study was to analyse the possible influence of functional variants of genes of OCTN cation transporters on the carnitine ester profile of patients with CD. Genotyping for SLC22A4 1672C → T, SLC22A5-207G → C mutations and three common NOD2 variants (R702W, G908R and 1007finsC) were performed in 100 adult CD patients and in ninety-four healthy controls by direct sequencing. The carnitine ester profile was determined using ESI triple quadrupole tandem MS. Contrary to the NOD2/CARD15 mutations, none of the SLC variants showed increased prevalence in the CD group, the prevalence of TC haplotype did not differ between the patients and the controls. In the mixed group of CD patients the fasting propionyl-(0.243 (SEM 0.008) v. 0.283 (SEM 0.014) mmol/l), butyryl- (0.274 (SEM 0.009) v. 0.301 (SEM 0.013)) and isovalerylcarnitine (0.147 (SEM 0.006) v. 0.185 (SEM 0.009)) levels were decreased; while the level of octenoyl- (0.086 (SEM 0.006) v. 0.069 (SEM 0.005)), myristoleyl- (0.048 (SEM 0.003) v. 0.037 (SEM 0.003)), palmitoyl- (0.140 (SEM 0.005) v. 0.122 (SEM 0.004)) and oleylcarnitine (0.172 (SEM 0.006) v. 0.156 (SEM 0.008); P

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KW - OCTN1

KW - OCTN2

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