Plasma amino acid concentration under human growth hormone treatment in uremic children

A. Szabó, E. Kenesei, T. Tulassay, P. Sallay, L. Szücs, I. Nagy

Research output: Contribution to journalArticle

Abstract

The plasma amino acid concentrations were investigated before and after 3 and 30 months of human recombinant growth hormone treatment in 7 children with chronic renal failure. The concentrations of amino acids in plasma showed characteristic changes (pretreatment vs. after 3 and 30 months of treatment): Lys 113 ± 33 vs. 162 ± 27 and 109 ± 38 μmol/l, Met 21 ± 8 vs. 31 ± 4 and 16 ± 5, Thrl05 ± 23 vs. 148 ± 60 and 118 ± 30, Ala 455 ± 109 vs. 536 ± 93 and 314 ± 60, Gin 298 ± 66 vs. 277 ± 52 and 544 ± 65, Glu 168 ± 46 vs. 209 ± 57 and 96 ± 24, Gly345 ± 137 vs. 479 ± 169 and 342 ± 95, Pro 378 ± 148 vs. 422 ± 28 and 527 ± 229, OH-Pro 33 ± 17 vs. 105 ± 23 and 97 ± 35, Se 133 ± 39 vs. 178 ± 55 and 131 ± 12 μmol/l. Long-term treatment with human recombinant growth hormone normalized plasma alanine, glutamine, and glutamic acid levels, increased the OH-Pro concentration, and did not alter the amino acid ratios of Gly/Val, Phe/Tyr, Ser/Gly, and Asn/Asp, but the Gln/Glu ratio approached the normal value.

Original languageEnglish
Pages (from-to)265-267
Number of pages3
JournalHormone Research in Paediatrics
Volume44
Issue number6
DOIs
Publication statusPublished - 1995

Fingerprint

Human Growth Hormone
Amino Acids
Growth Hormone
Glutamine
Alanine
Chronic Kidney Failure
Glutamic Acid
Reference Values
Therapeutics
hydroxide ion

Keywords

  • Chronic renal failure
  • Growth hormone treatment
  • Plasma amino acid concentration

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

Plasma amino acid concentration under human growth hormone treatment in uremic children. / Szabó, A.; Kenesei, E.; Tulassay, T.; Sallay, P.; Szücs, L.; Nagy, I.

In: Hormone Research in Paediatrics, Vol. 44, No. 6, 1995, p. 265-267.

Research output: Contribution to journalArticle

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AU - Nagy, I.

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