We investigated whether the level of plasma adenosine (ADO) changed during exercise and whether this could be related to exercise-induced bronchoconstriction. Baseline levels of ADO did not differ, but exercise resulted in higher ADO in patients with asthma than in healthy subjects (86 ± 35 vs 59 ± 16 nmol/L; P <.001). In patients with asthma, the increase in ADO was related to decreases in FEV1 (r2 = 0.475; P <.05) and SaO2 (r2 = 0.693; P <.05). These data suggest that adenosine might be involved in the development of exercise-induced bronchoconstriction.
- Exercise-induced bronchoconstriction
ASJC Scopus subject areas
- Immunology and Allergy