Plasma adenosine concentration increases during exercise: A possible contributing factor in exercise-induced bronchoconstriction in asthma

Éva Vizi, Éva Huszár, Zsuzsa Csoma, György Böszörményi-Nagy, Erzsébet Barát, Ildikó Horváth, Irén Herjavecz, Márk Kollai

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

We investigated whether the level of plasma adenosine (ADO) changed during exercise and whether this could be related to exercise-induced bronchoconstriction. Baseline levels of ADO did not differ, but exercise resulted in higher ADO in patients with asthma than in healthy subjects (86 ± 35 vs 59 ± 16 nmol/L; P <.001). In patients with asthma, the increase in ADO was related to decreases in FEV1 (r2 = 0.475; P <.05) and SaO2 (r2 = 0.693; P <.05). These data suggest that adenosine might be involved in the development of exercise-induced bronchoconstriction.

Original languageEnglish
Pages (from-to)446-448
Number of pages3
JournalJournal of Allergy and Clinical Immunology
Volume109
Issue number3
DOIs
Publication statusPublished - Mar 2002

Keywords

  • Adenosine
  • Asthma
  • Exercise-induced bronchoconstriction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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