Plasma 6β-hydroxycortisol measurements for assessing altered hepatic drug metabolizing enzyme activity

Nikolette Szücs, I. Varga, A. Patócs, M. Tóth, Csilla Jakab, E. Gláz, K. Rácz

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To study the usefulness of 6β-hydroxycortisol (6βOHF) measurements for assessing hepatic drug metabolizing enzyme activity, plasma 6βOHF and cortisol were measured in 22 patients with alcoholic liver disease after at least 2 weeks of alcohol abstinence, in 5 patients with severe Cushing's syndrome and in 12 healthy non-drinker subjects. Blood samples were drawn under resting conditions during midnight, in the morning at 0800 h, after a 1-mg overnight dexamethasone test and after ACTH administration. Plasma cortisol and 6βOHF were determined with radioimmunoassay. In patients with alcoholic liver disease, the plasma cortisol levels at midnight and 0800 h, as well as after the administration of dexamethasone and ACTH were not different from corresponding values measured in non-drinker controls. In addition, these patients with alcoholic liver disease had similar plasma 6βOHF levels at midnight, 0800 h and after dexamethasone administration as compared to corresponding values in controls. By contrast, ACTH administration in patients with alcoholic liver disease resulted in a significantly (p

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalActa Physiologica Hungarica
Volume90
Issue number3
DOIs
Publication statusPublished - 2003

Fingerprint

Alcoholic Liver Diseases
Liver
Adrenocorticotropic Hormone
Dexamethasone
Enzymes
Hydrocortisone
Pharmaceutical Preparations
Alcohol Abstinence
Cushing Syndrome
Radioimmunoassay

Keywords

  • 6β-hydroxycortisol
  • Alcohol abstinence
  • Chronic alcoholic liver disease
  • Cortisol
  • Cortisol metabolism drug metabolizing enzyme
  • Cushing's syndrome

ASJC Scopus subject areas

  • Physiology

Cite this

Plasma 6β-hydroxycortisol measurements for assessing altered hepatic drug metabolizing enzyme activity. / Szücs, Nikolette; Varga, I.; Patócs, A.; Tóth, M.; Jakab, Csilla; Gláz, E.; Rácz, K.

In: Acta Physiologica Hungarica, Vol. 90, No. 3, 2003, p. 217-223.

Research output: Contribution to journalArticle

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