Plants ectopically expressing the iron-binding protein, ferritin, are tolerant to oxidative damage and pathogens

Mária Deák, G. Horváth, Sholpan Davletova, Katalin Török, L. Sass, I. Vass, B. Barna, Z. Király, D. Dudits

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Transgenic tobacco plants that synthesize alfalfa ferritin in vegetative tissues - either in its processed form in chloroplasts or in the cytoplasmic nonprocessed form - retained photosynthetic function upon free radical toxicity generated by iron excess or paraquat treatment. Progeny of transgenic plants accumulating ferritin in their leaves exhibited tolerance to necrotic damage caused by viral (tobacco necrosis virus) and fungal (Alternaria alternata, Botrytis cinerea) infections. These transformants exhibited normal photosynthetic function and chlorophyll content under greenhouse conditions. We propose that by sequestering intracellular iron involved in generation of the very reactive hydroxyl radicals through a Fenton reaction, ferritin protects plant cells from oxidative damage induced by a wide range of stresses.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalNature Biotechnology
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1999

Fingerprint

Iron-Binding Proteins
Tobacco
Pathogens
Ferritins
Genetically Modified Plants
Iron
Greenhouses
Chlorophyll
Free radicals
Viruses
Botrytis
Toxicity
Alternaria
Paraquat
Medicago sativa
Plant Cells
Chloroplasts
Tissue
Hydroxyl Radical
Free Radicals

Keywords

  • Iron
  • Necrosis
  • Paraquat
  • Reactive oxygen species
  • Stress

ASJC Scopus subject areas

  • Microbiology

Cite this

Plants ectopically expressing the iron-binding protein, ferritin, are tolerant to oxidative damage and pathogens. / Deák, Mária; Horváth, G.; Davletova, Sholpan; Török, Katalin; Sass, L.; Vass, I.; Barna, B.; Király, Z.; Dudits, D.

In: Nature Biotechnology, Vol. 17, No. 2, 02.1999, p. 192-196.

Research output: Contribution to journalArticle

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