Plant glutathione peroxidases: Structural and functional characterization, their roles in plant development

Krisztina Bela, Sajid Ali Khan Bangash, Jolán Csiszár

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Glutathione peroxidase (GPX) enzymes (EC 1.11.1.9, EC 1.11.1.12 and EC 1.11.1.15) are widespread among eukaryotic organisms and have pivotal role in peroxide detoxification. Detailed phylogenetic analysis of thiol peroxidases, including eukaryotic peroxiredoxins (PRXs) and eukaryotic GPXs, has revealed that plant glutathione peroxidases are more closely related to mammalian hydroperoxide peroxidases than to fungal GPXs, and a more precise name for them should be glutathione peroxidase-like (GPXL) enzymes. Plant GPXLs are mostly monomeric proteins that use the thioredoxin (TRX) system more effectively than the glutathione system during the reduction of H2O2 and lipid peroxides. GPXLs were suggested to be a putative link between the glutathione-based and the thioredoxin-based detoxifying systems. They possess some functional overlaps with the PRXs and glutathione transferases (GSTs), with respect to the maintenance of H2O2 homeostasis by the elimination of peroxides, and are also involved in the regulation of the redox homeostasis by maintaining the thiol-disulfide balance. In addition GPXs have been shown to perform other functions, including acting as redox transducers in abscisic acid (ABA) regulated responses, drought stress signaling, and redox-associated modification of nuclear proteins. Plant GPXLs not only protect cells from stress-induced oxidative damage, but they have also implicated in the regulation of processes associated with plant growth and development. Among these processes, their involvement in plant regeneration and shoot organogenesis is discussed.

Original languageEnglish
Title of host publicationGlutathione in Plant Growth, Development, and Stress Tolerance
PublisherSpringer International Publishing
Pages99-111
Number of pages13
ISBN (Electronic)9783319666822
ISBN (Print)9783319666815
DOIs
Publication statusPublished - Nov 21 2017

Keywords

  • Glutathione
  • Glutathione peroxidases
  • Plant development
  • Thioredoxin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Engineering(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Bela, K., Bangash, S. A. K., & Csiszár, J. (2017). Plant glutathione peroxidases: Structural and functional characterization, their roles in plant development. In Glutathione in Plant Growth, Development, and Stress Tolerance (pp. 99-111). Springer International Publishing. https://doi.org/10.1007/978-3-319-66682-2_4