Planning of empirical antibiotic therapy for women with pelvic inflammatory diseases: A geographical area-specific study

J. Skapinyecz, I. Smid, Ágnes Juhász, Cs Jeney, F. Rozgonyi, P. Kovács

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: Elaboration of an empiric antibiotic regimen for women with pelvic inflammatory disease (PID) for a geographical area in eastern Hungary. Study design: Pathogens were identified by culturing or polymerase chain reaction (PCR) from 2215 patients with suspected PID between 1 January 1999 and 31 December 2001. Empiric guidelines for PID treatment were based on susceptibility testing of the recovered bacteria, patient acceptance and cost-effectiveness of drugs and recommendations of earlier studies. Results: Chlamydia trachomatis was detected in 11%, Neisseria gonorrhoeae in 2%, Streptococcus spp. in 17%, Enterococcus spp. 9%, genital mycoplasmas in 25%, all obligate anaerobic pathogens in 30% of the patients. All antibiotics chosen for our regimen were effective in vitro against one or more recovered pathogens at least in 80%; this regimen produced 98% clinical cure rate in mild cases of PID. Conclusion: Early detection and prompt empirical antimicrobial therapy adapted to the local microflora and its resistance pattern can lead to good clinical results.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume111
Issue number2
DOIs
Publication statusPublished - Dec 10 2003

Fingerprint

Pelvic Inflammatory Disease
Anti-Bacterial Agents
Hungary
Neisseria gonorrhoeae
Mycoplasma
Chlamydia trachomatis
Enterococcus
Therapeutics
Streptococcus
Cost-Benefit Analysis
Guidelines
Bacteria
Polymerase Chain Reaction
Pharmaceutical Preparations

Keywords

  • Empirical antibiotic therapy
  • Local susceptibility testing
  • Pelvic inflammatory disease

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Planning of empirical antibiotic therapy for women with pelvic inflammatory diseases : A geographical area-specific study. / Skapinyecz, J.; Smid, I.; Juhász, Ágnes; Jeney, Cs; Rozgonyi, F.; Kovács, P.

In: European Journal of Obstetrics Gynecology and Reproductive Biology, Vol. 111, No. 2, 10.12.2003, p. 183-188.

Research output: Contribution to journalArticle

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