Planning of empirical antibiotic therapy for women with pelvic inflammatory diseases: A geographical area-specific study

J. Skapinyecz, I. Smid, Ágnes Juhász, Cs Jeney, F. Rozgonyi, P. Kovács

Research output: Contribution to journalArticle

3 Citations (Scopus)


Objective: Elaboration of an empiric antibiotic regimen for women with pelvic inflammatory disease (PID) for a geographical area in eastern Hungary. Study design: Pathogens were identified by culturing or polymerase chain reaction (PCR) from 2215 patients with suspected PID between 1 January 1999 and 31 December 2001. Empiric guidelines for PID treatment were based on susceptibility testing of the recovered bacteria, patient acceptance and cost-effectiveness of drugs and recommendations of earlier studies. Results: Chlamydia trachomatis was detected in 11%, Neisseria gonorrhoeae in 2%, Streptococcus spp. in 17%, Enterococcus spp. 9%, genital mycoplasmas in 25%, all obligate anaerobic pathogens in 30% of the patients. All antibiotics chosen for our regimen were effective in vitro against one or more recovered pathogens at least in 80%; this regimen produced 98% clinical cure rate in mild cases of PID. Conclusion: Early detection and prompt empirical antimicrobial therapy adapted to the local microflora and its resistance pattern can lead to good clinical results.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number2
Publication statusPublished - Dec 10 2003



  • Empirical antibiotic therapy
  • Local susceptibility testing
  • Pelvic inflammatory disease

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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