Planar chromatography: Current status and future perspectives in pharmaceutical analysis - I. Applicability, quantitation and validation

Gábor Szepesi, S. Nyiredy

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The most important features of capillary action planar chromatographic methods are summarized. Certain properties such as case in operation, sensitivity to experimental conditions, stationary and mobile phase selection, phase system optimization, separation efficiency and detection possibilities are discussed only briefly. Other aspects such as the applicability of planar chromatographic methods in pharmaceutical analysis, quantitation and validation are considered in more detail. The advantages and limitations of different evaluation techniques (visual comparison, spot elution techniques and in situ densitometry) are also discussed. Validation steps specific to planar chromatographic methods are emphasized.

Original languageEnglish
Pages (from-to)1007-1015
Number of pages9
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume10
Issue number10-12
DOIs
Publication statusPublished - 1992

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Chromatography
Pharmaceutical Preparations
Capillary Action
Densitometry

Keywords

  • pharmaceutical analysis
  • Planar chromatography
  • quantitation.
  • thin-layer chromatography
  • validation

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science

Cite this

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KW - validation

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