Placental protein 4 as a possible tumor marker in ovarian tumors

P. M. Göcze, D. G. Szabò, G. N. Than, K. F. Krommer, I. F. Csaba, H. Bohn

Research output: Contribution to journalArticle

4 Citations (Scopus)


Placental protein 4 (PP-4), a recently characterized glycoprotein from human placenta, was studied using a specific double-antibody radioimmunoassay in sera of 130 volunteers, 76 ovarian tumor patients and in ovarian tumor cyst fluid and ascites of 21 patients. Elevated levels (> 3 γg/1) were found in 45 of 52 ovarian cancer patients (86.5%). PP-4 levels correlated significantly with staging. 31 patients with malignant ovarian tumor were monitored on 2-9 occasions during 5-82 weeks. Rising or falling levels of PP-4 correlated with progression or regression of disease in 25 of 31 instances (80.6%). Elevated levels were found in 10 of 24 benign and borderline ovarian tumors. Elevated PP-4 level does not indicate malignancy in each case. PP-4 can be regarded as tumor-associated antigen and a tumor marker in oncological practice.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalGynecologic and Obstetric Investigation
Issue number2
Publication statusPublished - Jan 1 1991


  • Follow-up
  • Ovarian tumor
  • Placental protein 4
  • Radioimmunoassay
  • Tumor cyst fluid
  • Tumor marker

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

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