Placental protein 4 as a possible tumor marker in ovarian tumors

P. M. Göcze, D. G. Szabò, G. Than, K. F. Krommer, I. F. Csaba, H. Bohn

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Placental protein 4 (PP-4), a recently characterized glycoprotein from human placenta, was studied using a specific double-antibody radioimmunoassay in sera of 130 volunteers, 76 ovarian tumor patients and in ovarian tumor cyst fluid and ascites of 21 patients. Elevated levels (> 3 γg/1) were found in 45 of 52 ovarian cancer patients (86.5%). PP-4 levels correlated significantly with staging. 31 patients with malignant ovarian tumor were monitored on 2-9 occasions during 5-82 weeks. Rising or falling levels of PP-4 correlated with progression or regression of disease in 25 of 31 instances (80.6%). Elevated levels were found in 10 of 24 benign and borderline ovarian tumors. Elevated PP-4 level does not indicate malignancy in each case. PP-4 can be regarded as tumor-associated antigen and a tumor marker in oncological practice.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalGynecologic and Obstetric Investigation
Volume32
Issue number2
DOIs
Publication statusPublished - 1991

Fingerprint

Pregnancy Proteins
Tumor Biomarkers
Neoplasms
Cyst Fluid
Ovarian Cysts
Neoplasm Antigens
Ascites
Ovarian Neoplasms
Placenta
Radioimmunoassay
Volunteers
Glycoproteins
Antibodies
Serum

Keywords

  • Follow-up
  • Ovarian tumor
  • Placental protein 4
  • Radioimmunoassay
  • Tumor cyst fluid
  • Tumor marker

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Göcze, P. M., Szabò, D. G., Than, G., Krommer, K. F., Csaba, I. F., & Bohn, H. (1991). Placental protein 4 as a possible tumor marker in ovarian tumors. Gynecologic and Obstetric Investigation, 32(2), 107-111. https://doi.org/10.1159/000293006

Placental protein 4 as a possible tumor marker in ovarian tumors. / Göcze, P. M.; Szabò, D. G.; Than, G.; Krommer, K. F.; Csaba, I. F.; Bohn, H.

In: Gynecologic and Obstetric Investigation, Vol. 32, No. 2, 1991, p. 107-111.

Research output: Contribution to journalArticle

Göcze, PM, Szabò, DG, Than, G, Krommer, KF, Csaba, IF & Bohn, H 1991, 'Placental protein 4 as a possible tumor marker in ovarian tumors', Gynecologic and Obstetric Investigation, vol. 32, no. 2, pp. 107-111. https://doi.org/10.1159/000293006
Göcze, P. M. ; Szabò, D. G. ; Than, G. ; Krommer, K. F. ; Csaba, I. F. ; Bohn, H. / Placental protein 4 as a possible tumor marker in ovarian tumors. In: Gynecologic and Obstetric Investigation. 1991 ; Vol. 32, No. 2. pp. 107-111.
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