Placental protein 4 as a possible marker for monitoring gynaecological tumours

P. M. Gocze, D. G. Szabo, G. Than, K. F. Krommer, I. F. Csaba, H. Bohn

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Radioimmunoassay procedure was developed to measure the placental protein 4 (PP-4) in serum. The standard curve covered a range from 0.9-200 μg/l. The upper limit of concentration of normal sera was defined as 3.0 μg/l. In 27% of pregnancies, 0% of patients with intact trophoblastic tumours, 42% of patients with endometrial cancer, 44% of patients with cervical cancer, 84% of patients with ovarian cancer and 100% of patients with vulvar cancer the serum concentration was found to be above the limit value. In patients with trophoblastic tumours during and after the treatment PP-4 levels temporarily increased, which could be explained by destruction of tumour cells. This report is the first to study PP-4 concentration in patients with trophoblastic tumours and vulvar carcinomas.

Original languageEnglish
Pages (from-to)407-408
Number of pages2
JournalMedical Science Research
Volume16
Issue number8
Publication statusPublished - 1988

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Pregnancy Proteins
Tumors
Trophoblastic Neoplasms
Monitoring
Neoplasms
Serum
Vulvar Neoplasms
Cells
Endometrial Neoplasms
Uterine Cervical Neoplasms
Ovarian Neoplasms
Radioimmunoassay
Carcinoma
Pregnancy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Gocze, P. M., Szabo, D. G., Than, G., Krommer, K. F., Csaba, I. F., & Bohn, H. (1988). Placental protein 4 as a possible marker for monitoring gynaecological tumours. Medical Science Research, 16(8), 407-408.

Placental protein 4 as a possible marker for monitoring gynaecological tumours. / Gocze, P. M.; Szabo, D. G.; Than, G.; Krommer, K. F.; Csaba, I. F.; Bohn, H.

In: Medical Science Research, Vol. 16, No. 8, 1988, p. 407-408.

Research output: Contribution to journalArticle

Gocze, PM, Szabo, DG, Than, G, Krommer, KF, Csaba, IF & Bohn, H 1988, 'Placental protein 4 as a possible marker for monitoring gynaecological tumours', Medical Science Research, vol. 16, no. 8, pp. 407-408.
Gocze, P. M. ; Szabo, D. G. ; Than, G. ; Krommer, K. F. ; Csaba, I. F. ; Bohn, H. / Placental protein 4 as a possible marker for monitoring gynaecological tumours. In: Medical Science Research. 1988 ; Vol. 16, No. 8. pp. 407-408.
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