PLAZENTAPROTEIN 12 (PP 12)/INSULIN LIKE GROWTH-FACTOR BINDING PROTEIN (IGF-BP) IN DER SCHWANGERSCHAFT VON STOFFWECHSELGESUNDEN UND DIABETIKERINNEN MIT RETINOPATHIE

Translated title of the contribution: Placental protein 12 (PP 12)/insulin like growth-factor binding protein (IGF-bp) in normal pregnancy compared with diabetes complicated by retinopathy

V. Briese, G. N. Than, D. G. Szabo, R. R. Strache, E. Glockner, A. Szilagyi, H. Hopp

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Abstract

The placental protein 12 (PP 12) was found to be identical with the insulin like growth-factor binding protein (IGF-bp). In present investigations serum samples of 420 healthy pregnant women between 7th and 40th weeks of gestation were proved regarding to their IGF-bp concentrations by means of a radioimmunoassay. For each pregnancy week means and standard deviations were estimated. IGF-bp serum concentrations continuously increased up to the 18th week (140 ± 40 μg/l); followed by decreasing of the values up to the 30th week (102 ± 44 μg/l) and then slightly increased up to term (121 ± 46 μg/l). In addition the IGF-bp estimations were performed in maternal serum samples of 45 diabetic pregnant women complicated by retinopathia diabetica benigna as well as proliferativa; sum total 101 serum samples. In patients with benign retinopathy 82% (12/68) and in patients of proliferative retinopathy 85% (5/33) of the IGF-bp values were increased above the two times standard deviation.

Original languageGerman
Pages (from-to)1215-1219
Number of pages5
JournalZentralblatt fur Gynakologie
Volume111
Issue number18
Publication statusPublished - Jan 1 1989

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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