Placental protein 12 levels of maternal and feta sera and amniotic fluid at delivery

Z. J. Bognar, G. Than, I. F. Csaba, D. Szabo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Placental protein 12 (PP12) was isolated from aqueous extracts of human placenta by Bohn and Krans in 1980. The authors have developed a radioimmunoassay method to measure simultaneously a small amount of PP12 in maternal, retroplacental, umbilical cord arterial and venous sera as well as amniotic fluid. P12 measurements were taken from samples obtained from 16 mothers undergoing vaginal delivery at gestational age of 37-41 weeks. Maternal serum concentration of PP12 at delivery was found to be (201,9 μg/l SD: 106,3) about 3 times higher than that measured in healthy, non-pregnant controls. PP12 levels in fetal sera proved to be independent of maternal PP12 levels. Its concentration in the umbilical artery and umbilical vein was both higher or lower, than that in maternal sera. Extremely high PP12 concentrations were found in the retroplacental sera (4450 μg/l SD: 3263,3) and the levels were found in the amniotic fluid were greater in fetal and maternal sera by several orders (23923,1 μg/l SD; 15834,9).

Original languageEnglish
Pages (from-to)1088
Number of pages1
JournalIRCS Medical Science
Volume9
Issue number12
Publication statusPublished - 1981

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Pregnancy Proteins
Amniotic Fluid
Mothers
Fluids
Serum
Umbilical Veins
Umbilical Arteries
Umbilical Cord
Placenta
Gestational Age
Radioimmunoassay

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Placental protein 12 levels of maternal and feta sera and amniotic fluid at delivery. / Bognar, Z. J.; Than, G.; Csaba, I. F.; Szabo, D.

In: IRCS Medical Science, Vol. 9, No. 12, 1981, p. 1088.

Research output: Contribution to journalArticle

Bognar, Z. J. ; Than, G. ; Csaba, I. F. ; Szabo, D. / Placental protein 12 levels of maternal and feta sera and amniotic fluid at delivery. In: IRCS Medical Science. 1981 ; Vol. 9, No. 12. pp. 1088.
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