Placental protein 12 (PP12) was isolated from aqueous extracts of human placenta by Bohn and Krans in 1980. The authors have developed a radioimmunoassay method to measure simultaneously a small amount of PP12 in maternal, retroplacental, umbilical cord arterial and venous sera as well as amniotic fluid. P12 measurements were taken from samples obtained from 16 mothers undergoing vaginal delivery at gestational age of 37-41 weeks. Maternal serum concentration of PP12 at delivery was found to be (201,9 μg/l SD: 106,3) about 3 times higher than that measured in healthy, non-pregnant controls. PP12 levels in fetal sera proved to be independent of maternal PP12 levels. Its concentration in the umbilical artery and umbilical vein was both higher or lower, than that in maternal sera. Extremely high PP12 concentrations were found in the retroplacental sera (4450 μg/l SD: 3263,3) and the levels were found in the amniotic fluid were greater in fetal and maternal sera by several orders (23923,1 μg/l SD; 15834,9).
|Number of pages||1|
|Journal||IRCS Medical Science|
|Publication status||Published - Jan 1 1981|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)