Placental protein 12: A potential marker for monitoring trophoblastic disease

G. Than, I. F. Csaba, Z. J. Bognar

Research output: Contribution to journalArticle

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Abstract

The placental protein 12 (PP12) is a 'new' protein, which was isolated by Bohn in 1980. The authors developed a radioimmunoassay and were able to detect PP12 in the sera of healthy pregnant women and describe 'normal' serum levels during pregnancy. Recently, those investigations have been extended to patients suffering from trophoblastic tumours. PP12 was present in trace amounts in healthy, nonpregnant controls (62 μg/l, SD: 26.0). Late pregnant-control level was three-times higher (190 μg/l, SD: 72.9). Elevated serum levels were found in 39 out of the 41 cases with chorial tumours. In hydatidiform mole (572 μg/l, SD: 466.7) and in chorioadenoma cases (600 χ/l, SD: 514.5), significantly higher PP12 values (p <0.01) were found than in control groups. In choriocarcinoma cases, values were similar to those found in normal late pregnancy. PP12 serum values decreased during treatment. Preliminary data suggest that this protein of unknown biological function can be regarded as a useful tumour-marker for the seromonitoring of trophoblastic tumour patients.

Original languageEnglish
Pages (from-to)1093
Number of pages1
JournalIRCS Medical Science
Volume9
Issue number12
Publication statusPublished - 1981

Fingerprint

Pregnancy Proteins
Monitoring
Trophoblastic Neoplasms
Tumors
Serum
Invasive Hydatidiform Mole
Hydatidiform Mole
Pregnancy
Choriocarcinoma
Level control
Tumor Biomarkers
Radioimmunoassay
Pregnant Women
Proteins
Control Groups
Neoplasms

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Placental protein 12 : A potential marker for monitoring trophoblastic disease. / Than, G.; Csaba, I. F.; Bognar, Z. J.

In: IRCS Medical Science, Vol. 9, No. 12, 1981, p. 1093.

Research output: Contribution to journalArticle

Than, G. ; Csaba, I. F. ; Bognar, Z. J. / Placental protein 12 : A potential marker for monitoring trophoblastic disease. In: IRCS Medical Science. 1981 ; Vol. 9, No. 12. pp. 1093.
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