Placental gene expression of the placental growth factor (PlGF) in intrauterine growth restriction

József Gábor Joó, J. Rigó, Balázs Börzsönyi, Csaba Demendi, László Kornya

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: We analyzed changes in gene expression of placental growth factor (PIGF) in human placental samples obtained postpartum from pregnancies with IUGR. Methods: During a twelve-month study period representing the calendar year of 2012 placental samples from 101 pregnancies with IUGR and from 140 normal pregnancies were obtained for analysis of a potential difference in PIGF gene expression. Results: There was no significant difference in gene activity of the PIGF gene between the IUGR versus normal pregnancy groups (Ln2α: 0.92; p < 0.06). Within the IUGR group, no fetal gender-dependent differences were seen in placental PIGF gene expression (Ln2α: 0.72; p = 0.05). Placental PIGF gene activity was significantly lower in fetuses with more severe IUGR versus less severe cases (Ln2α: −1.49; p < 0.03). Conclusion: We found no difference in gene expression of PIGF in placental samples obtained from IUGR pregnancies versus normal pregnancy suggesting the absence of a direct role of PIGF gene activity in the development of defective angiogenesis in IUGR during the later stages of gestation. However, in more severe cases of intrauterine growth restriction PIGF expression does show a significant decrease indicating its potential role in the profound defect in angiogenesis in these cases.

Original languageEnglish
Pages (from-to)1471-1475
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume30
Issue number12
DOIs
Publication statusPublished - Jun 18 2017

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Fetal Growth Retardation
Intercellular Signaling Peptides and Proteins
Gene Expression
Pregnancy
Growth
Genes
Postpartum Period
Fetus

Keywords

  • gene expression
  • intrauterine growth restriction
  • PIGF
  • placenta
  • placental growth factor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

Cite this

Placental gene expression of the placental growth factor (PlGF) in intrauterine growth restriction. / Joó, József Gábor; Rigó, J.; Börzsönyi, Balázs; Demendi, Csaba; Kornya, László.

In: Journal of Maternal-Fetal and Neonatal Medicine, Vol. 30, No. 12, 18.06.2017, p. 1471-1475.

Research output: Contribution to journalArticle

Joó, József Gábor ; Rigó, J. ; Börzsönyi, Balázs ; Demendi, Csaba ; Kornya, László. / Placental gene expression of the placental growth factor (PlGF) in intrauterine growth restriction. In: Journal of Maternal-Fetal and Neonatal Medicine. 2017 ; Vol. 30, No. 12. pp. 1471-1475.
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