PKCθ utility in diagnosing c-KIT/DOG-1 double negative gastrointestinal stromal tumors

Attila Kövecsi, Ioan Jung, Zoltan Szentirmay, Tivadar Bara, Tivadar Bara, Daniel Popa, Simona Gurzu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the diagnosis value of an immunohistochemical (IHC) panel of three antibodies for the diagnosis of gastrointestinal stromal tumors (GISTs). Material and methods: In 80 consecutive GISTs without lymph node metastases, the IHC examinations were performed using the antibodies CD117 (c-KIT), DOG-1 and c-theta (PKCθ) protein. The diagnostic value of PKCθ in c-KIT/DOG-1 negative GISTs has been explored in fewer than 10 Medline-indexed papers. Results: The c-KIT, PKCθ and DOG-1 positivity was noted in 92.50% (n = 74), 90% (n = 72) and 76.25% (n = 61) of the cases, respectively. All of the C-KIT negative cases (n = 6) were also DOG-1 negative but displayed PKCθ positivity. All of the DOG-1 positive cases (n = 61) also expressed c-KIT. No correlation between the examined markers and clinicopathological parameters was noted. Conclusions: The PKCθ sensitivity is similar to c-KIT and superior to DOG- 1 sensitivity. All of the c-KIT/DOG-1 negative GISTs seem to express PKCθ. For a proper diagnosis of GIST, the c-KIT/DOG-1/PKCθ panel should be used, with possible therapeutic but not prognostic value.

Original languageEnglish
Pages (from-to)55950-55957
Number of pages8
JournalOncotarget
Volume8
Issue number34
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • CD117
  • Diagnosis
  • GIST
  • Pathology section
  • Protein kinase
  • c-theta

ASJC Scopus subject areas

  • Oncology

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