Pituitary tumorigenesis: Role of regulation of wee1 kinase by microRNAs

Henriett Butz, Attila Patocs

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Mechanisms involved in pituitary tumorigenesis, especially of non-functional pituitary adenomas remain unclear. Various cell cycle inhibitors have been found to be underexpressed in pituitary tumors. However alterations of the G2/M checkpoint have not been revealed as a major player in the pathogenic process. Wee1 kinase, a nuclear protein that delays G2/M transition has been recently recognized as a tumor suppressor and has been found as a potential pathogenic factor in pituitary adenomagenesis. In this chapter after a brief summary of the cell cycle regulation, the biogenesis and function of miRs in pituitary adenomas, we review the role and function of Wee1 kinase focusing on its potential role in pituitary tumorigenesis. MicroRNAs posttranscriptionally regulating expression of Wee1 kinase and their expression and role in pituitary adenoma development are also discussed.

Original languageEnglish
Title of host publicationTumors of the Central Nervous System
Subtitle of host publicationPineal, Pituitary, and Spinal Tumors
PublisherSpringer Netherlands
Pages141-150
Number of pages10
Volume10
ISBN (Electronic)9789400756816
ISBN (Print)9789400756809
DOIs
Publication statusPublished - Jan 1 2013

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Pituitary tumorigenesis: Role of regulation of wee1 kinase by microRNAs'. Together they form a unique fingerprint.

  • Cite this

    Butz, H., & Patocs, A. (2013). Pituitary tumorigenesis: Role of regulation of wee1 kinase by microRNAs. In Tumors of the Central Nervous System: Pineal, Pituitary, and Spinal Tumors (Vol. 10, pp. 141-150). Springer Netherlands. https://doi.org/10.1007/978-94-007-5681-6_16