Pituitary adenylate cyclase activating polypeptide plays a role in olfactory memory formation in chicken

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30 Citations (Scopus)

Abstract

PACAP plays an important role during development of the nervous system and is also involved in memory processing. The aim of the present study was to investigate the function of PACAP in chicken embryonic olfactory memory formation by blocking PACAP at a sensitive period in ovo. Chicken were exposed daily to strawberry scent in ovo from embryonic day 15. Control eggs were treated only with saline, while other eggs received a single injection of the PACAP antagonist PACAP6-38 at day 15. The consumption of scented and unscented water was measured daily after hatching. Animals exposed to strawberry scent in ovo showed no preference. However, chickens exposed to PACAP6-38, showed a clear preference for plain water, similarly to unexposed chicken. Our present study points to PACAP's possible importance in embryonic olfactory memory formation.

Original languageEnglish
Pages (from-to)2344-2350
Number of pages7
JournalPeptides
Volume26
Issue number11
DOIs
Publication statusPublished - Nov 1 2005

Keywords

  • Chicken
  • Embryonic
  • Olfactory memory
  • PACAP

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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