Pituitary adenylate cyclase activating polypeptide is highly abundant in the nervous system of anoxia-tolerant turtle, Pseudemys scripta elegans

D. Reglödi, A. Somogyvári-Vigh, J. Vígh, M. Li, I. Lengvári, A. Arimura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The levels of the pituitary adenylate cyclase activating polypeptide (PACAP) were measured in the central nervous system and in peripheral organs of the anoxia-tolerant freshwater turtle, Pseudemys scripta elegans by radioimmunoassay. The concentration of PACAP38 was strikingly high in the central nervous system and lower but considerable immunoreactivity was detected in the peripheral organs. Levels of PACAP38 in the turtle brain exceed those measured in rat and human brain areas by 10-100-fold. Based on these exceptionally high levels of PACAP and the known neuroprotective role of the peptide, it can be suggested that PACAP38 plays a role in the extraordinary resistance of the turtle brain from anoxia-induced neuronal damage.

Original languageEnglish
Pages (from-to)873-878
Number of pages6
JournalPeptides
Volume22
Issue number6
DOIs
Publication statusPublished - Jun 21 2001

Keywords

  • Anoxia-tolerance
  • Neuroprotection
  • PACAP
  • Turtle

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Pituitary adenylate cyclase activating polypeptide is highly abundant in the nervous system of anoxia-tolerant turtle, Pseudemys scripta elegans'. Together they form a unique fingerprint.

  • Cite this