Phytoecdysteroids and vitamin d analogues - similarities in structure and mode of action

Noémi Tóth, Attila Hunyadi, M. Báthori, E. Zádor

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Phytoecdysteroids are plant steroids with identical or analogue structures to the molting hormone in arthropods. The ecdysteroids exert several beneficial effects on mammals, from which the most cited and deeply examined one is the increase of muscle size and strength. This shows similarities with the mode of action of the androgenic steroids but the ecdysteroids do not bind to the cytoplasmic/nuclear receptor of the mammalian steroids. These findings led to the hypothesis that ecdysteroids possibly bind to membrane bound receptors and they are likely to influence signal transduction pathways. Probably because of their closely related chemical structures, ecdysteroids exert some similar effects in vertebrates to those of the hormone 1,25-dihydroxyvitamin D3 (1,25D) which is produced in the kidney from 25-hydroxyvitamin D3, after being converted in the liver from Vitamin D3 1,25D generates biological responses via both genomic and rapid, nongenomic mechanisms. Structure-activity relationship studies with different Vitamin D analogues could open the possibility to show that the two ways of action (genomic and nongenomic) can be influenced separately The connection between the Vitamin D status and muscle function is already well-described in clinical studies, and several efforts have been made to evaluate the effect of Vitamin D deficiency or supplementation on muscle morphological changes and the underlying molecular mechanisms This paper aims to summarize the main structural commonalities between the ecdysteroids, 1,25D and other Vitamin D analogues. The similarities in their effects and pathways that might be involved in the mechanism of action of these compounds will also be discussed.

Original languageEnglish
Pages (from-to)1974-1994
Number of pages21
JournalCurrent Medicinal Chemistry
Volume17
Issue number18
DOIs
Publication statusPublished - 2010

Fingerprint

Ecdysteroids
Vitamins
Vitamin D
Calcitriol
Muscle
Steroids
Ecdysone
Calcifediol
Phytosterols
Muscles
Signal transduction
Vitamin D Deficiency
Mammals
Arthropods
Cholecalciferol
Muscle Strength
Structure-Activity Relationship
Cytoplasmic and Nuclear Receptors
Liver
Vertebrates

Keywords

  • Alternative ligand binding pocket
  • Conformational ensemble model
  • Ecdysteroid
  • Vitamin d analogues
  • Vitamin d receptor

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Phytoecdysteroids and vitamin d analogues - similarities in structure and mode of action. / Tóth, Noémi; Hunyadi, Attila; Báthori, M.; Zádor, E.

In: Current Medicinal Chemistry, Vol. 17, No. 18, 2010, p. 1974-1994.

Research output: Contribution to journalArticle

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