Phytocomponents identification in mistletoe (Viscum album) young leaves and branches, by GC-MS and antiproliferative effect on HEPG2 and McF7 cell lines

Daliborca C. Vlad, Roxana Popescu, Victor Dumitrascu, Adinela Cimporescu, Cristian S. Vlad, C. Vágvölgyi, Judith Krisch, Cristina Dehelean, Florin G. Horhat

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In the present work, aqueous and alcoholic extracts of Viscum album young leaves and branches were evaluated, in order to identify the most relevant constituents that confirm its biological activity. GC-MS was the employed technique used for separation and identification of the extracted components. Both extracts revealed the presence of important terpenoids, fatty acids and natural antioxidants such as vitamin E. The antiproliferative potential of the obtained extracts was also investigated on neoplastic cell lines, HepG2 and MCF-7. The alcoholic extract was more efficient and proved a significant cytotoxic effect at a concentration of 75 mg/mL, but inhibition of cell proliferation was also observed when the aqueous extract was used.

Original languageEnglish
Pages (from-to)82-87
Number of pages6
JournalFarmacia
Volume64
Issue number1
Publication statusPublished - 2016

Keywords

  • Cell proliferation
  • Cytotoxicity
  • GC-MS
  • Mistletoe
  • Viscum album

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Vlad, D. C., Popescu, R., Dumitrascu, V., Cimporescu, A., Vlad, C. S., Vágvölgyi, C., Krisch, J., Dehelean, C., & Horhat, F. G. (2016). Phytocomponents identification in mistletoe (Viscum album) young leaves and branches, by GC-MS and antiproliferative effect on HEPG2 and McF7 cell lines. Farmacia, 64(1), 82-87.