Physiology of the salivary glands

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Salivary gland products are essential for oral health. Saliva is produced by three pairs of major glands, the parotid, the submandibular and sublingual glands, and by numerous minor glands scattered around the oral cavity. Salivary water and electrolyte secretion is an energy-consuming active two-stage process. First the acini secrete primary isotonic saliva into the luminal terminal end pieces of the gland parenchyma. This saliva is then modified by electrolyte reabsorption to form a hypotonic secretion in the ductal systems. Salivary proteins are continuously synthesized, and stored in secretory granules within the cell. Both electrolyte and protein secretions are highly regulated processes. Electrolyte secretion is primarily stimulated by parasympathetic stimulation while protein secretion is preferentially activated by sympathetic stimulation, but there is a considerable cross-talk and synergy between the two regulatory pathways. Approximately 1.0-1.5 litres of saliva is secreted by healthy persons each day; consisting of water, electrolytes, lubricants, antimicrobial compounds, enzymes and growth factors. These components of saliva facilitate speech, mastication and swallowing, and initiate food digestion. In addition, they protect the oral mucosa and the teeth. Thus, saliva secreted into the oral cavity is essential to maintain physiological conditions in the mouth.

Original languageEnglish
Pages (from-to)581-586
Number of pages6
JournalSurgery
Volume33
Issue number12
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Salivary Glands
Saliva
Electrolytes
Mouth
Sublingual Gland
Salivary Proteins and Peptides
Lubricants
Water
Submandibular Gland
Mastication
Parotid Gland
Oral Health
Secretory Vesicles
Mouth Mucosa
Deglutition
Digestion
Intercellular Signaling Peptides and Proteins
Tooth
Proteins
Food

Keywords

  • Defence
  • electrolyte
  • molecular mechanism
  • parasympathetic
  • protein
  • regulation
  • saliva
  • salivary gland
  • secretion
  • sympathetic
  • water transport

ASJC Scopus subject areas

  • Surgery

Cite this

Physiology of the salivary glands. / Varga, G.

In: Surgery, Vol. 33, No. 12, 01.12.2015, p. 581-586.

Research output: Contribution to journalArticle

Varga, G. / Physiology of the salivary glands. In: Surgery. 2015 ; Vol. 33, No. 12. pp. 581-586.
@article{d0e507a34eaa45aa945b3a15b3c6b1b5,
title = "Physiology of the salivary glands",
abstract = "Salivary gland products are essential for oral health. Saliva is produced by three pairs of major glands, the parotid, the submandibular and sublingual glands, and by numerous minor glands scattered around the oral cavity. Salivary water and electrolyte secretion is an energy-consuming active two-stage process. First the acini secrete primary isotonic saliva into the luminal terminal end pieces of the gland parenchyma. This saliva is then modified by electrolyte reabsorption to form a hypotonic secretion in the ductal systems. Salivary proteins are continuously synthesized, and stored in secretory granules within the cell. Both electrolyte and protein secretions are highly regulated processes. Electrolyte secretion is primarily stimulated by parasympathetic stimulation while protein secretion is preferentially activated by sympathetic stimulation, but there is a considerable cross-talk and synergy between the two regulatory pathways. Approximately 1.0-1.5 litres of saliva is secreted by healthy persons each day; consisting of water, electrolytes, lubricants, antimicrobial compounds, enzymes and growth factors. These components of saliva facilitate speech, mastication and swallowing, and initiate food digestion. In addition, they protect the oral mucosa and the teeth. Thus, saliva secreted into the oral cavity is essential to maintain physiological conditions in the mouth.",
keywords = "Defence, electrolyte, molecular mechanism, parasympathetic, protein, regulation, saliva, salivary gland, secretion, sympathetic, water transport",
author = "G. Varga",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.mpsur.2015.09.003",
language = "English",
volume = "33",
pages = "581--586",
journal = "Surgery",
issn = "0263-9319",
publisher = "Elsevier BV",
number = "12",

}

TY - JOUR

T1 - Physiology of the salivary glands

AU - Varga, G.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Salivary gland products are essential for oral health. Saliva is produced by three pairs of major glands, the parotid, the submandibular and sublingual glands, and by numerous minor glands scattered around the oral cavity. Salivary water and electrolyte secretion is an energy-consuming active two-stage process. First the acini secrete primary isotonic saliva into the luminal terminal end pieces of the gland parenchyma. This saliva is then modified by electrolyte reabsorption to form a hypotonic secretion in the ductal systems. Salivary proteins are continuously synthesized, and stored in secretory granules within the cell. Both electrolyte and protein secretions are highly regulated processes. Electrolyte secretion is primarily stimulated by parasympathetic stimulation while protein secretion is preferentially activated by sympathetic stimulation, but there is a considerable cross-talk and synergy between the two regulatory pathways. Approximately 1.0-1.5 litres of saliva is secreted by healthy persons each day; consisting of water, electrolytes, lubricants, antimicrobial compounds, enzymes and growth factors. These components of saliva facilitate speech, mastication and swallowing, and initiate food digestion. In addition, they protect the oral mucosa and the teeth. Thus, saliva secreted into the oral cavity is essential to maintain physiological conditions in the mouth.

AB - Salivary gland products are essential for oral health. Saliva is produced by three pairs of major glands, the parotid, the submandibular and sublingual glands, and by numerous minor glands scattered around the oral cavity. Salivary water and electrolyte secretion is an energy-consuming active two-stage process. First the acini secrete primary isotonic saliva into the luminal terminal end pieces of the gland parenchyma. This saliva is then modified by electrolyte reabsorption to form a hypotonic secretion in the ductal systems. Salivary proteins are continuously synthesized, and stored in secretory granules within the cell. Both electrolyte and protein secretions are highly regulated processes. Electrolyte secretion is primarily stimulated by parasympathetic stimulation while protein secretion is preferentially activated by sympathetic stimulation, but there is a considerable cross-talk and synergy between the two regulatory pathways. Approximately 1.0-1.5 litres of saliva is secreted by healthy persons each day; consisting of water, electrolytes, lubricants, antimicrobial compounds, enzymes and growth factors. These components of saliva facilitate speech, mastication and swallowing, and initiate food digestion. In addition, they protect the oral mucosa and the teeth. Thus, saliva secreted into the oral cavity is essential to maintain physiological conditions in the mouth.

KW - Defence

KW - electrolyte

KW - molecular mechanism

KW - parasympathetic

KW - protein

KW - regulation

KW - saliva

KW - salivary gland

KW - secretion

KW - sympathetic

KW - water transport

UR - http://www.scopus.com/inward/record.url?scp=84948444550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948444550&partnerID=8YFLogxK

U2 - 10.1016/j.mpsur.2015.09.003

DO - 10.1016/j.mpsur.2015.09.003

M3 - Article

AN - SCOPUS:84948444550

VL - 33

SP - 581

EP - 586

JO - Surgery

JF - Surgery

SN - 0263-9319

IS - 12

ER -