Homologous serum accelerates the mast cell transformation of rat peritoneal cells and the maturation of mast cells in tissue culture while heterologous sera have no similar effect. This suggests that the blood transport of the mast cells is not a passive, but an active process and that serum is one of the inducers of maturation. The experiments indicate that the juvenile forms of the mast cells are transferred from the thymus to the peritoneal cavity, then to the blood and finally, after complete maturation, to the subcutaneous connective tissue. Cortisone fails to further increase the enhancing effect of the serum, but promotes degranulation.
|Number of pages||8|
|Journal||Acta Biologica Academiae Scientiarum Hungaricae|
|Publication status||Published - 1972|
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)