Physiological functions of presenilins; Beyond γ-secretase

Ibolya Stiller, Beáta Lizák, Gábor Bánhegyi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Presenilin (PS) was identified in screens for mutations causing the early onset forms of familial Alzheimer's disease (FAD) in 1995. As catalytic units of the γ-secretase complex, presenilins participate in the processing of amyloid beta protein (Aβ), the main component of deposits in brain of patients with AD. The more than 90 substrates of γ-secretase isolated so far demonstrate its contribution to wide range of cellular processes and signaling events. However, recent findings have revealed numerous γ-secretase-independent presenilin functions, including involvement in calcium homeostasis, endoplasmic reticulum (ER) stress and autophagy. This mini-review attempts to summarize the multiple physiological and pathological functions of presenilin.

Original languageEnglish
Pages (from-to)1019-1025
Number of pages7
JournalCurrent Pharmaceutical Biotechnology
Volume15
Issue number11
DOIs
Publication statusPublished - Jan 1 2014

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Keywords

  • Autophagy
  • Ca signaling
  • ER stress
  • Neurodegenerative disease
  • presenilin
  • γ-secretase

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

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