A vénák fiziológiás funkciói és intrinsic szabályozásuk.

Translated title of the contribution: PHysiological function of veins and their intrinsic regulation

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Physiological functions of the veins include: 1. Blood collectors with flow-rectifying valves; 2. Selective barrier function, venular reabsorption of fluid; 3. Capacity function and redistribution of the blood volume, pressure-damping; 4. Maintaining the filling pressure of the heart by adequate venous return at varying cardiac output; 5. Increasing orthostatic tolerance of the body; 6. Postcapillary resistance; 7. Angiogenesis (in venous side of the microcirculation); 8. Secretion of bioactive substances by the endothelial and smooth muscle cells; 9. Lymphocyte homing (high-endothelial venules); 10. Cooperation between venular endothelium and the polymorphonuclear leukocytes (margination and rolling); 11. Enhanced inhibition of platelet aggregation and thromboembolic reactions; 12. Other special functions (e.g. facial vein: contribution to cranial thermoregulation; internal jugular vein: antisiphonage "device", etc.). Recent results suggest: 1. that intrinsic biomechanical adaptation of the systemic vein wall may occur in response a) to fast pressure changes within the physiological range by myogenic capacity autoregulation of the lumen; b) to long-term physiological haemodynamic loading by increase in total capacity and in short-term myogenic autoregulation range without marked changes of the wall thickness; c) to chronic arterialization with compensatory increase in wall-thickness reducing the extreme mechanical stresses induced by arterial pressure (such changes also imply fibrotic transformation of the wall-structure); 2. EDRF physiologically released by venous endothelium seems to be an important factor protecting the veins against non-desirable increases of smooth muscle tone (e.g. at low Mg-ion level of extracellular fluid, or in case of axial overstretch of the vein, etc.).

Translated title of the contributionPHysiological function of veins and their intrinsic regulation
Original languageHungarian
Pages (from-to)1673-1684
Number of pages12
JournalOrvosi hetilap
Volume133
Issue number27
Publication statusPublished - Jul 5 1992

ASJC Scopus subject areas

  • Medicine(all)

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