A B9-vitamin élettani és kórélettani jelentősége

Összegzés a folsav táplálékkiegészítőként történő alkalmazásának 30. évfordulójára

Translated title of the contribution: Physiological and pathophysiological significance of Vitamin B9: Summary on the occasion of the 30-year introduction of folic acid as a dietary supplement

Zsigrai Sára, Kalmár Alexandra, Valcz Gábor, Szigeti Krisztina Andrea, Barták Barbara Kinga, Nagy Zsófia Brigitta, P. Igaz, Z. Tulassay, Molnár Béla

Research output: Contribution to journalArticle

Abstract

Vitamin B9, also known as folate, can be found in natural and synthetic forms, mostly in vegetables or folic acid containing food supplements. By participating in the proper cell development and division, its presence is indispensable for certain basic metabolic processes. The decreased folate level of the body, mainly caused by environmental and hereditary factors as well as aging, can lead to genetic, epigenetic and metabolic changes. It can be related to the development of megaloblastic anemia, various cardiovascular diseases (such as atherosclerosis, stroke) obstetrical complications (such as abruption of the placentae, spontaneous abortion, preterm delivery, neural tube defect), neu-ropsychiatric diseases (such as Alzheimer’s disease, Parkinson’s disease, depression) and tumors. The vitamin has a preventive effect in all the above-mentioned diseases, however, in the case of tumor existence, its therapeutic use requires great care, as it may promote the progression of certain precancerous lesions. Food fortification with folic acid is currently being carried out in more than 60 countries in order to ensure a minimum vitamin B9 requirement for the population and therefore to prevent the development of the diseases that are connected to folic acid deficiency. Due to its assumable role in carcinogenesis, an initial concern had taken place when fortification was implemented (1998), however, the present statistical data do not confirm such adverse health effects. On the other hand, several beneficial properties can be connected to the vitamin, that can be the reason why more and more countries are considering to join this program. Besides the fact that folic acid is a widely used food supplement, it is also applied in oncological medicine (leucovorin) to increase the effectiveness of certain chemotherapeutical drugs (e.g. methotrexate, 5-fluorouracil).

Original languageHungarian
Pages (from-to)1087-1096
Number of pages10
JournalOrvosi hetilap
Volume160
Issue number28
DOIs
Publication statusPublished - Jan 1 2019

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Dietary Supplements
Folic Acid
Vitamins
Folic Acid Deficiency
Megaloblastic Anemia
Leucovorin
Neural Tube Defects
Therapeutic Uses
Spontaneous Abortion
Epigenomics
Methotrexate
Fluorouracil
Vegetables
Cell Division
Placenta
Parkinson Disease
Neoplasms
Atherosclerosis
Alzheimer Disease
Carcinogenesis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A B9-vitamin élettani és kórélettani jelentősége : Összegzés a folsav táplálékkiegészítőként történő alkalmazásának 30. évfordulójára. / Sára, Zsigrai; Alexandra, Kalmár; Gábor, Valcz; Andrea, Szigeti Krisztina; Kinga, Barták Barbara; Brigitta, Nagy Zsófia; Igaz, P.; Tulassay, Z.; Béla, Molnár.

In: Orvosi hetilap, Vol. 160, No. 28, 01.01.2019, p. 1087-1096.

Research output: Contribution to journalArticle

Sára, Zsigrai ; Alexandra, Kalmár ; Gábor, Valcz ; Andrea, Szigeti Krisztina ; Kinga, Barták Barbara ; Brigitta, Nagy Zsófia ; Igaz, P. ; Tulassay, Z. ; Béla, Molnár. / A B9-vitamin élettani és kórélettani jelentősége : Összegzés a folsav táplálékkiegészítőként történő alkalmazásának 30. évfordulójára. In: Orvosi hetilap. 2019 ; Vol. 160, No. 28. pp. 1087-1096.
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AU - Andrea, Szigeti Krisztina

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