Physicochemical testing of free films containing non-soluble components

E. Bölcskei, G. Regdon, K. Süvegh, T. Marek, K. Pintye-Hódi

Research output: Contribution to journalArticle

Abstract

Eudragit® L 30D-55 films containing diclofenac sodium in different concentrations (0%, 1%, and 5%) were studied by conventional physicochemical methods and positron annihilation spectroscopy. Diclofenac sodium was found to change the properties of the film formed significantly. Positron annihilation spectroscopy was applied to track the Eudragit-diclofenac interaction. The presence of diclofenac initially led to significant distortion of the structure of the pure Eudragit film. However, during storage (17°C, 65% relative humidity), the distorted structure relaxed because of water uptake from the air. At the end of the storage period, the free-volume size was almost the same in all films.

Original languageEnglish
Pages (from-to)1020-1024
Number of pages5
JournalPolymers for Advanced Technologies
Volume23
Issue number6
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Diclofenac
Positron annihilation spectroscopy
Testing
Sodium
Free volume
Atmospheric humidity
Water
Air
methylmethacrylate-methacrylic acid copolymer

Keywords

  • Breaking strength
  • Free films
  • Positron annihilation spectroscopy

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

Physicochemical testing of free films containing non-soluble components. / Bölcskei, E.; Regdon, G.; Süvegh, K.; Marek, T.; Pintye-Hódi, K.

In: Polymers for Advanced Technologies, Vol. 23, No. 6, 06.2012, p. 1020-1024.

Research output: Contribution to journalArticle

@article{5db20423736a4790ac677ee9af07cca7,
title = "Physicochemical testing of free films containing non-soluble components",
abstract = "Eudragit{\circledR} L 30D-55 films containing diclofenac sodium in different concentrations (0{\%}, 1{\%}, and 5{\%}) were studied by conventional physicochemical methods and positron annihilation spectroscopy. Diclofenac sodium was found to change the properties of the film formed significantly. Positron annihilation spectroscopy was applied to track the Eudragit-diclofenac interaction. The presence of diclofenac initially led to significant distortion of the structure of the pure Eudragit film. However, during storage (17°C, 65{\%} relative humidity), the distorted structure relaxed because of water uptake from the air. At the end of the storage period, the free-volume size was almost the same in all films.",
keywords = "Breaking strength, Free films, Positron annihilation spectroscopy",
author = "E. B{\"o}lcskei and G. Regdon and K. S{\"u}vegh and T. Marek and K. Pintye-H{\'o}di",
year = "2012",
month = "6",
doi = "10.1002/pat.2009",
language = "English",
volume = "23",
pages = "1020--1024",
journal = "Polymers for Advanced Technologies",
issn = "1042-7147",
publisher = "John Wiley and Sons Ltd",
number = "6",

}

TY - JOUR

T1 - Physicochemical testing of free films containing non-soluble components

AU - Bölcskei, E.

AU - Regdon, G.

AU - Süvegh, K.

AU - Marek, T.

AU - Pintye-Hódi, K.

PY - 2012/6

Y1 - 2012/6

N2 - Eudragit® L 30D-55 films containing diclofenac sodium in different concentrations (0%, 1%, and 5%) were studied by conventional physicochemical methods and positron annihilation spectroscopy. Diclofenac sodium was found to change the properties of the film formed significantly. Positron annihilation spectroscopy was applied to track the Eudragit-diclofenac interaction. The presence of diclofenac initially led to significant distortion of the structure of the pure Eudragit film. However, during storage (17°C, 65% relative humidity), the distorted structure relaxed because of water uptake from the air. At the end of the storage period, the free-volume size was almost the same in all films.

AB - Eudragit® L 30D-55 films containing diclofenac sodium in different concentrations (0%, 1%, and 5%) were studied by conventional physicochemical methods and positron annihilation spectroscopy. Diclofenac sodium was found to change the properties of the film formed significantly. Positron annihilation spectroscopy was applied to track the Eudragit-diclofenac interaction. The presence of diclofenac initially led to significant distortion of the structure of the pure Eudragit film. However, during storage (17°C, 65% relative humidity), the distorted structure relaxed because of water uptake from the air. At the end of the storage period, the free-volume size was almost the same in all films.

KW - Breaking strength

KW - Free films

KW - Positron annihilation spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=84860516153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860516153&partnerID=8YFLogxK

U2 - 10.1002/pat.2009

DO - 10.1002/pat.2009

M3 - Article

VL - 23

SP - 1020

EP - 1024

JO - Polymers for Advanced Technologies

JF - Polymers for Advanced Technologies

SN - 1042-7147

IS - 6

ER -