Physicochemical stability and aerosolization performance of mannitol-based microcomposites

A. Pomázi, R. Ambrus, P. Szabó-Révész

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The aim of this work was to test the stability of mannitol-based co-spray-dried microcomposites containing meloxicam for use as dry powder inhalers. The effects of temperature and relative humidity (RH) on the physicochemical properties and aerosolization performance were investigated and the effects of polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) were analysed. Accelerated stability tests performed at 40 ± 2°C and 75 ± 5% RH during 6 months demonstrated that the mannitol-based microcomposites containing meloxicam, PVA and L-leucine were more stable than those containing PVP against RH and temperature. As concerns water uptake, the number of hydrogen-bonds was lower after storage in the case of the samples containing PVP, and the fine particle fraction, which determines the aerosolization parameter, therefore decreased below 50%. Such a composition may serve as an innovative drug delivery system for local lung treatment in the anti-inflammatory and mono- and combination therapy of cancer, pulmonary fibrosis and pain.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalJournal of Drug Delivery Science and Technology
Volume24
Issue number4
Publication statusPublished - 2014

Fingerprint

meloxicam
Povidone
Mannitol
Humidity
Polyvinyl Alcohol
Dry Powder Inhalers
Temperature
Pulmonary Fibrosis
Drug Delivery Systems
Leucine
Hydrogen
Anti-Inflammatory Agents
Pain
Lung
Water
Therapeutics
Neoplasms

Keywords

  • Accelerated stability test
  • Aerodynamic performance
  • Co-spray-dried
  • DPI form
  • Meloxicam
  • Microcomposites

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Physicochemical stability and aerosolization performance of mannitol-based microcomposites. / Pomázi, A.; Ambrus, R.; Szabó-Révész, P.

In: Journal of Drug Delivery Science and Technology, Vol. 24, No. 4, 2014, p. 397-403.

Research output: Contribution to journalArticle

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